Synthesis, characterization and in vivo evaluation of biocompatible ferrogels
| Autor: | Ana B. Bonhome-Espinosa, J. D. G. Durán, Modesto T. López-López, Laura Rodríguez-Arco, Víctor Carriel, Fernando Campos, Ismael Rodríguez, Andrey Zubarev |
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| Přispěvatelé: | [Lopez-Lopez, M. T.] Univ Granada, Dept Appl Phys, Granada, Spain, [Rodriguez-Arco, L.] Univ Granada, Dept Appl Phys, Granada, Spain, [Bonhome-Espinosa, A. B.] Univ Granada, Dept Appl Phys, Granada, Spain, [Duran, J. D. G.] Univ Granada, Dept Appl Phys, Granada, Spain, [Lopez-Lopez, M. T.] Inst Invest Biosanitaria ibs GRANADA, Granada, Spain, [Rodriguez, I. A.] Inst Invest Biosanitaria ibs GRANADA, Granada, Spain, [Rodriguez-Arco, L.] Inst Invest Biosanitaria ibs GRANADA, Granada, Spain, [Carriel, V.] Inst Invest Biosanitaria ibs GRANADA, Granada, Spain, [Bonhome-Espinosa, A. B.] Inst Invest Biosanitaria ibs GRANADA, Granada, Spain, [Campos, F.] Inst Invest Biosanitaria ibs GRANADA, Granada, Spain, [Duran, J. D. G.] Inst Invest Biosanitaria ibs GRANADA, Granada, Spain, [Rodriguez, I. A.] Univ Granada, Dept Histol, Tissue Engn Grp, Granada, Spain, [Carriel, V.] Univ Granada, Dept Histol, Tissue Engn Grp, Granada, Spain, [Campos, F.] Univ Granada, Dept Histol, Tissue Engn Grp, Granada, Spain, [Zubarev, A.] Ural Fed Univ, Dept Math Phys, Ekaterinburg, Russia, MINECO, Spain, ERDF, European Union - Spanish MINECO(Instituto CarlosIII), ERDF of the European Union, Russian Scientific Foundation |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Materials science
Biocompatibility CELL CULTURE HYDROGELS Magnetic particles Nanotechnology 02 engineering and technology Magnetic particle inspection RHEOLOGICAL PROPERTY 010402 general chemistry 01 natural sciences MAGNETISM BIOCOMPATIBILITY APPLIED MAGNETIC FIELDS MAGNETO-RHEOLOGY Rheology RHEOLOGY HISTOLOGY MAGNETIC BUBBLES IN-VIVO Scaffolds chemistry.chemical_classification FERROGEL IN VIVO MAGNETIC PARTICLE INFLAMMATORY RESPONSE RHEOLOGICAL MEASUREMENTS POLYMER Polymer MAGNETIC FIELDS 021001 nanoscience & nanotechnology Condensed Matter Physics BIOMECHANICS 0104 chemical sciences Electronic Optical and Magnetic Materials Characterization (materials science) chemistry TISSUE Self-healing hydrogels Ferrogels Nanoparticles Magnetic nanoparticles Particle POLYMERS 0210 nano-technology human activities MAGNETORHEOLOGY |
| Zdroj: | J Magn Magn Mater Journal of Magnetism and Magnetic Materials Digibug: Repositorio Institucional de la Universidad de Granada Universidad de Granada (UGR) Digibug. Repositorio Institucional de la Universidad de Granada Consejo Superior de Investigaciones Científicas (CSIC) |
| Popis: | A hydrogel is a 3-Dnetwork of polymer chains in which water is the dispersion medium. Hydrogels have found extensive applications inthe biomedical field due to their resemblance to living tissues.Furthermore, hydrogels can be endowedwith exceptionalproperties by addition of syntheticmaterials. For example, magneticfield-sensitive gels, called ferrogels, are obtained by embedding magnetic particles in the polymer network. Novelliving tissueswith unique magnetic field-sensitive propertieswere recently preparedby 3-D cell culture in biocompatible ferrogels. This talk critically reviews the most recent progress and perspectives intheirsynthesis, characterizationand biocompatibility evaluation. Optimizationof ferrogels for this novel applicationrequires low-density, strongly magnetic, multi-domain particles. Interestingly, the rheological properties of the resulting ferrogelsin the absence of field were largely enhanced with respect to nonmagnetic tissues, which can only be explained by the additional cross-linking imparted by the embeddedmagnetic particles.Remarkably, rheological measurements under an applied magnetic fielddemonstrated that magnetic tissuespresented reversibly tunable mechanical properties, which constitutes a unique advantage with respect to nonmagnetic tissues. In vivo evaluation of ferrogelsshowed good biocompatibility, with only some local inflammatoryresponse, and noparticle migrationor damage to distant organs. Financial support: project FIS2013-41821-R (MINECO, Spain; co-funded by ERDF, European Union); project FIS PI14-1343 funded by the Spanish MINECO (Instituto Carlos III), co-funded by the ERDF of the European Union; AZ also acknowledges the Russian Scientific Foundation, project 14-19-00989. |
| Databáze: | OpenAIRE |
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