Autoimmune Dementia: Clinical Course and Predictors of Immunotherapy Response
| Autor: | Daniel A. Drubach, Bradley F. Boeve, Keith A. Josephs, Max R. Trenerry, Eoin P. Flanagan, Joseph E. Parisi, Jayawant N. Mandrekar, Andrew McKeon, Jeffrey W. Britton, Sean J. Pittock, Val J. Lowe, Vanda A. Lennon, K. Meng Tan |
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| Rok vydání: | 2010 |
| Předmět: |
Autoimmune disease
medicine.medical_specialty genetic structures business.industry medicine.medical_treatment Autoantibody General Medicine Immunotherapy medicine.disease Methylprednisolone Prednisone Cation channel complex Internal medicine mental disorders Immunology medicine Dementia Original Article business Pleocytosis medicine.drug |
| Zdroj: | Mayo Clinic Proceedings. 85:881-897 |
| ISSN: | 0025-6196 |
| Popis: | OBJECTIVE To define the diagnostic characteristics and predictors of treatment response in patients with suspected autoimmune dementia. PATIENTS AND METHODS Between January 1, 2002, and January 1, 2009, 72 consecutive patients received immunotherapy for suspected autoimmune dementia. Their baseline clinical, radiologic, and serologic characteristics were reviewed and compared between patients who were responsive to immunotherapy and those who were not. Patients were classified as responders if the treating physician had reported improvement after immunotherapy (documented in 80% by the Kokmen Short Test of Mental Status, neuropsychological testing, or both). RESULTS Initial immunotherapeutic regimens included methylprednisolone in 56 patients (78%), prednisone in 12 patients (17%), dexamethasone in 2 patients (3%), intravenous immune globulin in 1 patient (1%), and plasma exchange in 1 patient (1%). Forty-six patients (64%) improved, most in the first week of treatment. Thirty-five percent of these immunotherapy responders were initially diagnosed as having a neurodegenerative or prion disorder. Pretreatment and posttreatment neuropsychological score comparisons revealed improvement in almost all cognitive domains, most notably learning and memory. Radiologic or electroencephalographic improvements were reported in 22 (56%) of 39 patients. Immunotherapy responsiveness was predicted by a subacute onset ( P P P =.007), shorter delay to treatment ( P =.005), seropositivity for a cation channel complex autoantibody ( P =.01; neuronal voltage-gated potassium channel more than calcium channel or neuronal acetylcholine receptor), and elevated cerebrospinal fluid protein (>100 mg/dL) or pleocytosis ( P =.02). Of 26 immunotherapy-responsive patients followed up for more than 1 year, 20 (77%) relapsed after discontinuing immunotherapy. CONCLUSION Identification of clinical and serologic clues to an autoimmune dementia allows early initiation of immunotherapy, and maintenance if needed, thus favoring an optimal outcome. |
| Databáze: | OpenAIRE |
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