Impact of Sarcopenia and Frailty in a Multicenter Cohort of Polypathological Patients
Autor: | Rocío Fernández-Ojeda, Máximo Bernabeu-Wittel, Jesús Díez-Manglano, Manuel Ollero-Baturone, Marta Muniesa, Fernando Salgado, Álvaro González-Molina, María Soto-Martín, Juan Gómez-Salgado |
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Rok vydání: | 2019 |
Předmět: |
medicine.medical_specialty
Sarcopenia Population lcsh:Medicine 030204 cardiovascular system & hematology Logistic regression Article 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Low body mass index 030212 general & internal medicine education Polypathological patients education.field_of_study Frailty business.industry lcsh:R Multimorbidity General Medicine medicine.disease Skeletal muscle mass musculoskeletal system Cohort Functional status Observational study business human activities |
Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname Zaguán. Repositorio Digital de la Universidad de Zaragoza Journal of Clinical Medicine Volume 8 Issue 4 Arias Montano. Repositorio Institucional de la Universidad de Huelva Journal of Clinical Medicine, Vol 8, Iss 4, p 535 (2019) |
Popis: | The prevalence, relationships and outcomes of sarcopenia and frailty in polypathological patients remain unknown. We performed a multicenter prospective observational study in six hospitals in order to assess prevalence, clinical features, outcome and associated risk factors of sarcopenia and frailty in a hospital-based population of polypathological patients. The cohort was recruited by performing prevalence surveys every 14 days during the inclusion period (March 2012&ndash June 2016). Sarcopenia was assessed by means of EWGSOP criteria and frailty by means of Fried&rsquo s criteria. Skeletal muscle mass was measured by tetrapolar bioimpedanciometry. All patients were followed for 12 months. Factors associated with sarcopenia, frailty and mortality were analyzed by multivariate logistic regression, and Kaplan&ndash Meier curves. A total of 444 patients (77.3 ± 8.4 years, 55% males) were included. Sarcopenia was present in 97 patients (21.8%), this being moderate in 54 (12.2%), and severe in 43 (9.6%) frailty was present in 278 patients (62.6%), and 140 (31.6%) were pre-frail combined sarcopenia and frailty were present in the same patient in 80 (18%) patients. Factors independently associated to the presence of both, sarcopenia and frailty were female gender, older age, different chronic conditions, poor functional status, low body mass index, asthenia and depressive disorders, and low leucocytes and lymphocytes count. Mortality in the 12-months follow-up period was 40%. Patients with sarcopenia, frailty or both survived significantly less than those without these conditions. Sarcopenia and frailty are frequent and interrelated conditions in polypathological patients, shadowing their survival. Their early recognition and management could improve health-related outcomes in this population. |
Databáze: | OpenAIRE |
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