Risk factors for vitamin D deficiency in patients with Crohn's disease
| Autor: | Tetsuya Kato, Tsuneya Nakamura, Kazuo Hara, Masahiro Tajika, Masahiko Kato, Yasutoshi Muto, Kenji Yamao, Akira Matsuura, Akira Sawaki, Takashi Suzuki, Kenji Ookubo |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Disease Comorbidity Gastroenterology vitamin D deficiency Crohn Disease Risk Factors Internal medicine medicine Vitamin D and neurology Prevalence Humans Ileitis Risk factor Vitamin D Crohn's disease business.industry Middle Aged medicine.disease Colitis Vitamin D Deficiency digestive system diseases Osteopenia Endocrinology Logistic Models Ferritins Female business |
| Zdroj: | Journal of gastroenterology. 39(6) |
| ISSN: | 0944-1174 |
| Popis: | Although the pathogenesis of osteopenia in Crohn's disease is not established, vitamin D deficiency is thought to be an important risk factor. However, little is known about the prevalence of vitamin D deficiency in patients with Crohn's disease in Japan. This study aimed to clarify the prevalence of vitamin D deficiency in patients with Crohn's disease in Japan and to examine the possible causes of the deficiency.We investigated serum 25-hydroxyvitamin D (25-OHD) levels, various laboratory parameters, and patient histories in 33 outpatients (25 men, 8 women; median age, 37 years; range, 26-57 years) and 15 age- and sex-matched healthy controls (8 men, 7 women; median age, 37 years; range, 24-57 years) and assessed risk factors for vitamin D deficiency.Although patients with Crohn's disease did not have significantly lower serum concentrations of 25-OHD than controls, 9 of 33 patients (27.3%) were considered vitamin D deficient (serum 25-OHD level/=10 ng/ml) compared with only 1 of 15 (6.7%) controls. Serum 25-OHD levels were significantly related to disease duration ( r = 0.46, P = 0.003), Crohn's Disease Activity Index (CDAI) score ( r = 0.44, P = 0.005), International Organization for the Study of Inflammatory Bowel Disease score ( r = 0.30, P0.05), and serum values of ferritin ( r = 0.34, P = 0.03), C-reactive protein ( r = 0.34, P = 0.03), total cholesterol ( r = 0.31, P = 0.04), and intact parathyroid hormone ( r = 0.23, P0.05). A logistic regression analysis was performed to investigate the ability of variables to predict low or normal 25-OHD values. Results showed that disease duration ( P = 0.03) and CDAI score ( P = 0.04) could predict the occurrence of vitamin D deficiency ( r(2) = 0.472, P = 0.0004).Vitamin D deficiency exists in patients with Crohn's disease in Japan. 25-OHD levels should be assessed in patients who have had Crohn's disease for a long time (15 years) and who have been in the active stage of the disease for long periods. |
| Databáze: | OpenAIRE |
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