Regional Brain Activation during Verbal Declarative Memory in Metastatic Breast Cancer
| Autor: | Misty L. Mahaffey, F. Chris Bennett, David Spiegel, Shelli R. Kesler |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Pathology Hydrocortisone Population Breast Neoplasms Neuropsychological Tests Article Breast cancer Memory Internal medicine Humans Medicine Neoplasm Metastasis education Prefrontal cortex Memory Disorders education.field_of_study medicine.diagnostic_test Recall Verbal Behavior business.industry Brain Cancer Middle Aged medicine.disease Magnetic Resonance Imaging Metastatic breast cancer Female Verbal memory business Functional magnetic resonance imaging |
| Zdroj: | Clinical Cancer Research. 15:6665-6673 |
| ISSN: | 1557-3265 1078-0432 |
| DOI: | 10.1158/1078-0432.ccr-09-1227 |
| Popis: | Purpose: To determine the neurofunctional basis of verbal memory dysfunction in women with metastatic breast cancer. This objective was based on previous research suggesting memory and other cognitive deficits in this population. We attempted to determine if verbal memory impairments were related to the most commonly studied disease parameters including adjuvant chemotherapy and chronic stress-related disruption of limbic system structures. Experimental Design: We used functional magnetic resonance imaging to test our hypothesis that women with breast cancer would show significantly lower brain activation during verbal declarative memory tasks compared with age and education-matched healthy female controls. We also assessed several stress-related variables including diurnal cortisol levels to test our hypothesis that women with breast cancer would show higher stress and this would contribute to brain activation deficits during memory tasks. Results: Women with breast cancer had significantly lower prefrontal cortex activation during the memory encoding condition compared with controls. However, the breast cancer group showed significantly greater activation than controls during the recall condition in multiple, diffuse brain regions. There were no significant differences between the groups in stress-related variables. Women who were treated with cyclophosphamide, methotrexate, and 5-fluorouracil chemotherapy showed lower prefrontal cortex activation during memory encoding. Conclusions: These results suggest that women with metastatic breast cancer may be at risk for verbal memory impairments as a result of altered functional brain activation profiles. These findings may be associated with chemotherapy type and/or other aspects of the breast cancer disease process. (Clin Cancer Res 2009;15(21):6665–73) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|