Cyclothialidine, a novel DNA gyrase inhibitor. I. Screening, taxonomy, fermentation and biological activity
| Autor: | Junko Watanabe, Tsutomu Kamiyama, Mikio Arisawa, Shoichi Ohoichi, Hisao Shimada, Naoki Nakada, Sayoko Sawairi |
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| Rok vydání: | 1994 |
| Předmět: |
Microbial Sensitivity Tests
medicine.disease_cause DNA gyrase Peptides Cyclic Microbiology chemistry.chemical_compound Heterocyclic Compounds Drug Discovery medicine Escherichia coli Animals Topoisomerase II Inhibitors Pyrroles Antibacterial agent Streptomyces filipinensis Pharmacology chemistry.chemical_classification biology Streptomycetaceae fungi biology.organism_classification Streptomyces Micrococcus luteus Enzyme chemistry Biochemistry Fermentation bacteria Cattle DNA |
| Zdroj: | The Journal of antibiotics. 47(1) |
| ISSN: | 0021-8820 |
| Popis: | Streptomyces filipinensis NR 0484 produced a new DNA gyrase inhibitor, cyclothialidine 1∼3) . It showed potent activity against DNA gyrases from Escherichia coli and Micrococcus luteus |
| Databáze: | OpenAIRE |
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