Tumor necrosis factor alpha, interleukin 1 alpha, and interleukin 6 mRNA expressed by human astrocytoma cells after infection by three different strains ofToxoplasma gondii
| Autor: | J Ricard, Pierre Ambroise-Thomas, Hy. Pelloux, V. Bracchi, J. M. Verna, Y. Markowicz |
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| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_treatment
Alpha (ethology) Astrocytoma Biology Cell Line Microbiology Pathogenesis Interleukin 20 medicine Animals Humans RNA Messenger Interleukin 6 General Veterinary Interleukin-6 Tumor Necrosis Factor-alpha Interleukin Toxoplasma gondii General Medicine biology.organism_classification Infectious Diseases Cytokine Insect Science Immunology biology.protein Parasitology Tumor necrosis factor alpha Glioblastoma Toxoplasma Toxoplasmosis Interleukin-1 |
| Zdroj: | Parasitology Research. 80:271-276 |
| ISSN: | 1432-1955 0044-3255 |
| DOI: | 10.1007/bf02351866 |
| Popis: | The role of cytokines in the pathogenesis of toxoplasmosis remains unknown to a large extent, especially in the case of reactivation that occurs in immunocompromised patients. To assess the importance of tumor necrosis factor alpha (TNF alpha), interleukin 1 alpha (IL1 alpha), and interleukin 6 (IL6), we studied the expression of these three cytokines by human astrocytoma cells after infection by three different strains of Toxoplasma gondii. The virulent RH strain, the intermediate 76K strain, and the cystogenic Prugniaud strain did not induce significantly different levels of expression of the cytokine messenger RNAs when the cytokines were studied at 1, 3, 6, and 24 h after parasitic infection. These results could indicate that infection by T. gondii strains of different virulence do not involve strong differences in TNF alpha, IL1 alpha, or IL6 expression by human astrocytoma cells. |
| Databáze: | OpenAIRE |
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