Cutaneous hypersensitivity reactions to Psoroptes ovis and Der p 1 in sheep previously infested with P. ovis--the sheep scab mite
| Autor: | Mike Taylor, Hugh R. P. Miller, J. Machell, J.F. Huntley, A.H.M. van den Broek, Richard E.W Halliwell |
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| Rok vydání: | 2003 |
| Předmět: |
Mite Infestations
Time Factors Immunology Sheep Diseases Biology Immunoglobulin E Antibodies Arthropod Proteins Leukocyte Count Antigen medicine Mite Hypersensitivity Eosinophilia Animals Antigens Dermatophagoides Mast Cells Antigens Ovis Prausnitz–Küstner test Sheep Domestic Skin General Veterinary Psoroptidae biology.organism_classification Cysteine Endopeptidases Psoroptes ovis biology.protein medicine.symptom Antibody Granulocytes |
| Zdroj: | Veterinary immunology and immunopathology. 91(2) |
| ISSN: | 0165-2427 |
| Popis: | We have previously shown that infestation with Psoroptes ovis induces an IgE response and intense tissue eosinophilia, typical of a Type I hypersensitivity response [Parasite Immunol. 22 (2000) 407]. Intradermal tests (IDSTs) suggest that there are also delayed and Arthus-type responses to this parasite. In order to study the nature of ovine cutaneous reactions to P. ovis, naive controls and experimentally infested sheep (n = 5) were challenged intradermally with mite antigen. Challenge elicited immediate (P < 0.001) and delayed (P < 0.005) wheal reactions in sensitised sheep. At 6 (P < 0.02) and 30 h (P < 0.001) the predominant infiltrating cells were eosinophils. To explore the role of circulating antibodies, naive sheep (n = 5) were subjected to Prausnitz-Kustner (PK) tests. These elicited immediate (P < 0.02) but not delayed wheal reactions. At 6 h eosinophils (P < 0.001) dominated the infiltrate. These results suggest that P. ovis allergens provoke an IgE-dependent immediate and late phase response and a cell-mediated eosinophil-rich delayed-type hypersensitivity response (ER-DTH). |
| Databáze: | OpenAIRE |
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