Human Genomic Characterization of a Novel Locus-Specific Repetitive Sequence
| Autor: | Richard E. Kouri, Gualberto Ruano, Wan-Liang Li, Clark S. Huckaby |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Molecular Sequence Data Locus (genetics) Hybrid Cells Gene mutation Biology Polymerase Chain Reaction Sequence Homology Nucleic Acid Consensus Sequence Genetics Consensus sequence Animals Humans Repeated sequence Repetitive Sequences Nucleic Acid Polymorphism Genetic Base Sequence Genome Human Nucleic acid sequence Chromosome Mapping Cercopithecidae Hominidae DNA Pedigree Random Amplified Polymorphic DNA Technique Blotting Southern Minisatellite Genetic marker Female Human genome |
| Zdroj: | Genomics. 29:397-402 |
| ISSN: | 0888-7543 |
| Popis: | A novel human chromosome locus-specific repetitive sequence was identified and characterized using arbitrary PCR. The repeat monomer consensus sequence is 100 bp long, and there are a minimum of 140 to 160 copies of the repetitive sequence per haploid human genome. The repetitive sequence is highly clustered on 20q12 within a 200- to 400-kb region. The highly polymorphic repeat array is inherited in a stable Mendelian fashion. Hybridization analysis revealed detectable conservation of the repeated element only among hominoids and Old World monkeys, where repeat arrangements are also polymorphic. |
| Databáze: | OpenAIRE |
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