Evaluation of Serum Antioxidant Activity in Patients with Liver Pathology by the Chemiluminescent Method
| Autor: | Titov Vn, Sazhina Nn |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Serum
medicine.medical_specialty Antioxidant Free Radicals Bilirubin medicine.medical_treatment Radical Amidines Models Biological Antioxidants General Biochemistry Genetics and Molecular Biology law.invention chemistry.chemical_compound law Internal medicine medicine Humans In patient Chemiluminescence Liver Diseases Hydrogen Peroxide General Medicine Kinetics Antioxidant capacity Endocrinology chemistry Biochemistry Free radical oxidation Luminescent Measurements Luminol Oxidation-Reduction Liver pathology |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 158:287-289 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-014-2742-3 |
| Popis: | Total antioxidant activity of the serum in patients with liver pathology was assessed by two chemiluminescent methods based on different models of free radical oxidation: Hb-H2O2-luminol and ABAP-luminol. Comparative analysis showed a significant, but not high correlation of the results (r=0.798), which can be explained by different mechanisms of induction of free radicals and effects of various serum components (proteins and bilirubin) on the initiation process. The influence of aphysiological concentration of analyzed values manifested in the Hb-H2O2 model. Disagreement between the results of measurements was more pronounced in patients with abnormally high serum bilirubin content. The results suggested that ABAP-luminol chemiluminescent model is more preferable for evaluation of antioxidant activity in clinical practice. |
| Databáze: | OpenAIRE |
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