Where Have All the Rodents Gone? The Effects of Attrition in Experimental Research on Cancer and Stroke
Autor: | Constance Holman, Ulrich Dirnagl, Bob Siegerink, Sophie K. Piper, Ulrike Grittner, Jonathan Kimmelman, Andreas Antonios Diamantaras |
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Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
Animal Experimentation
0301 basic medicine Cancer Research QH301-705.5 Rodentia Biology General Biochemistry Genetics and Molecular Biology Statistical power Toxicology 03 medical and health sciences 0302 clinical medicine Neoplasms Statistics medicine Animals Computer Simulation Attrition ddc:610 Biology (General) Stroke General Immunology and Microbiology General Neuroscience Cancer Small sample medicine.disease Experimental research 030104 developmental biology Sample size determination Sample Size Meta-analysis General Agricultural and Biological Sciences Function and Dysfunction of the Nervous System 030217 neurology & neurosurgery |
Zdroj: | PLoS Biology, Vol 14, Iss 1, p e1002331 (2016) PLoS biology 14(1), e1002331 (2016). doi:10.1371/journal.pbio.1002331 |
ISSN: | 1545-7885 1544-9173 |
Popis: | Given small sample sizes, loss of animals in preclinical experiments can dramatically alter results. However, effects of attrition on distortion of results are unknown. We used a simulation study to analyze the effects of random and biased attrition. As expected, random loss of samples decreased statistical power, but biased removal, including that of outliers, dramatically increased probability of false positive results. Next, we performed a meta-analysis of animal reporting and attrition in stroke and cancer. Most papers did not adequately report attrition, and extrapolating from the results of the simulation data, we suggest that their effect sizes were likely overestimated. |
Databáze: | OpenAIRE |
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