The Use of Prostaglandin E1 and Blalock-Taussig Shunts in Neonates with Cyanotic Congenital Heart Disease
| Autor: | Robert F. Agnew, Richard Ignacio, Clif Hamilton, David A. Browdie, Bernard M. Altenburg, William J. Norberg |
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| Rok vydání: | 1979 |
| Předmět: |
Heart Defects
Congenital Male Prostaglandins E Synthetic Pulmonary and Respiratory Medicine Bradycardia Pulmonary Circulation congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Time Factors Partial Pressure Cyanotic congenital heart disease medicine.medical_treatment Subclavian Artery Pulmonary Artery chemistry.chemical_compound Internal medicine Heart Septum medicine Humans Infusions Parenteral Prostaglandin E1 Acidosis business.industry Infant Newborn Ductus Arteriosus Oxygen Shunting Catheter chemistry Anesthesia Cardiology Drug Evaluation Female Surgery medicine.symptom Cardiology and Cardiovascular Medicine business Shunt (electrical) Prostaglandin E |
| Zdroj: | The Annals of Thoracic Surgery. 27:508-513 |
| ISSN: | 0003-4975 |
| DOI: | 10.1016/s0003-4975(10)63359-0 |
| Popis: | Six unselected neonates with cyanotic congenital heart disease and life-threatening degrees of arterial oxygen desaturation have been managed by a protocol that includes administration of prostaglandin E 1 (PGE 1 ) and early Blalock-Taussig shunting. In 5 patients (seven paired observations) partial pressure of arterial oxygen (PaO 2 ) rose from 19 mm Hg to a mean of 32.9 mm Hg within 20 minutes of initiation of PGE 1 (0.1 to 0.2 μg/kg/hr), infused intravenously or through an aortic catheter placed at ductal level or with both methods. The nonresponsive patient was older than the patients showing a positive response (1 month versus 24 to 96 hours). Following catheterization, immediate palliative operation including a Blalock-Taussig shunt was carried out. Although all had a satisfactory PaO 2 (mean, 49 mm Hg) postoperatively, the PGE 1 -nonresponsive patient experienced serious intraoperative bradycardia, hypotension, and acidosis in contrast to the PGE 1 -responsive group. In this study, the use of PGE 1 was not associated with any apparent serious side effects. |
| Databáze: | OpenAIRE |
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