Growth and Shape Modelling of the Rabbit Tibia: Study of the Dynamics of Developing Skeleton
| Autor: | G. Superti, Ugo E. Pazzaglia, Francesco Spagnuolo, Marcella Marchese, Guido Zarattini |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Aging Biology Bone growth Bone remodelling Osteogenesis Bone cell medicine Animals Tibia Growth Plate Process (anatomy) Bone modelling Endochondral ossification Growth plate cartilage Mechanostatic theory General Veterinary Cartilage Dynamics (mechanics) General Medicine Anatomy Skeleton (computer programming) Resorption Apposition medicine.anatomical_structure Animals Newborn Bone Remodeling Rabbits |
| Popis: | Summary The proliferative impulse of the growth plate cartilage and related structures and its effect on the dimensions of long bones are well documented. The modulation of shape, however, is less known, and in general, it is referred to the coupled resorption/apposition process of bone modelling. A morphometric study was carried out on rabbit tibiae comparing size increments and shape changes in relation to age. Utilizing measurements made using dried bones, radiography and computerized tomography, it was possible to perform a three-dimensional analysis of shape modulation occurring during a period of growth extending from 3 months to 1 year of age. The dynamics of the shape changes related to growth were studied with a fluorescent tetracycline labelling. This enabled correlation of shape modulation with the 3-D distribution of apposition and resorption. The current thinking behind the influences and mechanical forces affecting bone architecture was discussed in the light of these findings. Several factors play a role in the structural organization of the human and upper vertebrates’ skeleton, whose shape is genetically determined in the complex process usually referred as ‘modelling’. This does not conflict with the existing evidence of remodelling being influenced by mechanical stimuli, but the unsolved question remains how physical forces (strains) act on the biological substrate of cartilage and bone cells. |
| Databáze: | OpenAIRE |
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