Storage proteins are driving pediatric hazelnut allergy in a lipid transfer protein-rich area
| Autor: | Anna Ringauf, Mónica Martínez-Blanco, Daniel Lozano-Ojalvo, Guadalupe Marco, Israel Thuissard-Vasallo, Marta Reche, Inmaculada Toboso, Teresa Valbuena, Elena Molina |
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| Přispěvatelé: | Fundación de la Sociedad Española de Alergia e Inmunología Clínica |
| Rok vydání: | 2021 |
| Předmět: |
Allergy
component-resolved diagnosis Component-resolved diagnosis Health (social science) specific IgE severity TP1-1185 Plant Science Immunoglobulin E Health Professions (miscellaneous) Microbiology Article Severity food challenge Skin-prick test Medicine Storage protein hazelnut allergy Sensitization chemistry.chemical_classification biology skin-prick test business.industry Oral food challenge Chemical technology Food challenge food and beverages medicine.disease respiratory tract diseases medicine.anatomical_structure Hazelnut allergy Specific IgE chemistry Immunology biology.protein Sunflower seed business Plant lipid transfer proteins Food Science |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname Foods Volume 10 Issue 10 Foods, Vol 10, Iss 2463, p 2463 (2021) |
| Popis: | This article belongs to the Special Issue Molecular Approaches to Food Allergy Diagnosis, Treatment and Identification of Allergens. Oral food challenge (OFC) remains the gold standard for the diagnosis of food allergies. However, this test is not without risks, given that severe allergic reactions can be triggered while it is conducted. The purpose of this study is to identify potential demographic variables, clinical characteristics of the patients and biomarkers that may be associated with severe reactions during the hazelnut oral challenge test. The sample included 22 children allergic to hazelnut who underwent a tree nut skin prick test (SPT), specific IgE (sIgE) to hazelnut, component-resolved diagnosis (CRD) with different hazelnut allergens (Cor a 1, Cor a 8, Cor a 9, Cor a 11, Cor a 14), and a single-blind placebo-controlled challenge with hazelnut. A statistically significant relationship was found between the severity of the reaction and the highest values of sIgE to hazelnut, Cor a 11 and Cor a 14, cumulative symptom-triggering dose and sunflower seed sensitization. The use of the CRD is a useful tool to identify patients at higher risk of developing a severe reaction. In this pediatric population sample from Spain, storage proteins were confirmed to be most involved in hazelnut allergy and the development of severe reactions. This research was funded by SEAIC Foundation of the Spanish Society of Allergy and Clinical Immunology. |
| Databáze: | OpenAIRE |
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