Sexual Dimorphism in the Blood Pressure Response to Angiotensin II in Mice After Angiotensin-converting Enzyme Blockade
| Autor: | Porter H. Glover, Jane F. Reckelhoff, Marcia Venegas-Pont, Julio C. Sartori-Valinotti, Michael J. Ryan |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Mean arterial pressure Kidney Cortex Angiotensin-Converting Enzyme Inhibitors Blood Pressure Peptide hormone Article Mice Enalapril Internal medicine Renin–angiotensin system Internal Medicine medicine Animals Vasoconstrictor Agents F2-Isoprostanes Sex Characteristics Kidney biology Superoxide Dismutase business.industry Angiotensin II Drug Synergism Angiotensin-converting enzyme Catalase Mice Inbred C57BL Proteinuria Blood pressure medicine.anatomical_structure Endocrinology biology.protein Female business medicine.drug |
| Zdroj: | American Journal of Hypertension. 23:92-96 |
| ISSN: | 1941-7225 0895-7061 |
| DOI: | 10.1038/ajh.2009.203 |
| Popis: | BACKGROUND The incidence of hypertension and progression of renal disease are greater in men than in women. Data suggest that there is a dimorphic response to angiotensin II (Ang II) in rats, with male rats exhibiting a greater increase in mean arterial pressure (MAP) than females. However, during endogenous renin-angiotensin system (RAS) blockade with angiotensin-converting enzyme (ACE) inhibition, female rats have a greater MAP response to Ang II. We tested whether female mice exhibit a greater MAP response to chronic Ang II during ACE inhibition. METHODS Twenty-week-old male and female C57BL/6J mice (n > or = 6/group), treated with enalapril (40 mg/kg/day in drinking water), were assigned to groups receiving either Ang II (800 ng/kg/min) or saline for 2 weeks. Enalapril treatment began 4 days before and continued throughout the experiment. RESULTS MAP was higher in male mice than female mice treated with enalapril and Ang II (male: 144 +/- 3 vs. female: 121 +/- 6 mm Hg, P < 0.05) and was not different between mice treated with enalapril alone (male: 99 +/- 3 vs. female: 100 +/- 3 mm Hg). F2-isoprostanes were not increased by Ang II; however, female mice had significantly higher levels than males. Renal cortical expression of catalase and Cu/Zn-superoxide dismutase (SOD) was not different between experimental groups. Urinary protein was higher in male mice when compared to females, but was not changed after treatment with Ang II in either group. CONCLUSIONS These data suggest that there are species and sex-specific differences in the mechanism of the blood pressure response to Ang II, even during ACE inhibition. |
| Databáze: | OpenAIRE |
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