The lysosomal membrane-export of metabolites and beyond
| Autor: | Sönke Rudnik, Markus Damme |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Biochemistry 03 medical and health sciences symbols.namesake 0302 clinical medicine Organelle Animals Humans Molecular Biology chemistry.chemical_classification Organelles Catabolism Chemistry Peripheral membrane protein Lysosome-Associated Membrane Glycoproteins Membrane Transport Proteins Cell Biology Compartment (chemistry) Intracellular Membranes Golgi apparatus Cell biology Amino acid 030104 developmental biology Cytoplasm 030220 oncology & carcinogenesis symbols Lysosomes Function (biology) |
| Zdroj: | The FEBS journalReferences. 288(14) |
| ISSN: | 1742-4658 |
| Popis: | Lysosomes are degradative organelles in eukaryotic cells mediating the hydrolytic catabolism of various macromolecules to small basic building blocks. These low-molecular-weight metabolites are transported across the lysosomal membrane and reused in the cytoplasm and other organelles for biosynthetic pathways. Even though in the past 20 years our understanding of the lysosomal membrane regarding various transporters, other integral and peripheral membrane proteins, the lipid composition, but also its turnover has dramatically improved, there are still many unresolved questions concerning key aspects of the function of the lysosomal membrane. These include a possible function of lysosomes as a cellular storage compartment, yet unidentified transporters mediating the export such as various amino acids, mechanisms mediating the transport of lysosomal membrane proteins from the Golgi apparatus to lysosomes, and the turnover of lysosomal membrane proteins. Here, we review the current knowledge about the lysosomal membrane and identify some of the open questions that need to be solved in the future for a comprehensive and complete understanding of how lysosomes communicate with other organelles, cellular processes, and pathways. |
| Databáze: | OpenAIRE |
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