Human CD4+ T-cell recognition of influenza A virus hemagglutinin after subunit vaccination
| Autor: | C M Gelder, B A Askonas, J. R. Lamb |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Protein subunit Immunology Hemagglutinin (influenza) Hemagglutinins Viral Hemagglutinin Glycoproteins Influenza Virus medicine.disease_cause Microbiology H5N1 genetic structure Epitope Antigenic drift Virus Virology Influenza A virus medicine Humans biology Vaccination virus diseases Middle Aged Influenza Vaccines Insect Science biology.protein Female Research Article |
| Zdroj: | Journal of virology. 70(7) |
| ISSN: | 0022-538X |
| Popis: | We have examined human CD4+ T-cell recognition of influenza A/Beijing/32/92 (H3N2) virus hemagglutinin following influenza virus HANA subunit vaccination. CD4+ T-cell repertoires were dominated by recognition of epitopes located in conserved regions of the molecule, in a major histocompatibility complex class II haplotype-dependent manner, analogous to that observed following natural infection. |
| Databáze: | OpenAIRE |
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