Beneficial effects of combinatorial micronutrition on body fat and atherosclerosis in mice

Autor: Gianpaolo Rando, Christine Lohmann, Christian M. Matter, Walter Wahli, Ilhem El Kochairi, Alexandra Montagner
Přispěvatelé: Université de Lausanne (UNIL), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), University Hospital Zurich, Bioresearch & Partners SA (Monthey, Switzerland), the Swiss National Science Foundation through grants to W.W. (310030-113404) and C.M.M. (33CM30-124112), Bonizzi-Theler Foundation, University of Zurich, Wahli, W, Wahli, Walter
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Male
Apolipoprotein B
Physiology
[SDV]Life Sciences [q-bio]
Peroxisome proliferator-activated receptor
Adipose tissue
030204 cardiovascular system & hematology
PPARα
Mice
0302 clinical medicine
2737 Physiology (medical)
prevention
3T3-L1 Cells
Adipose Tissue/metabolism
Adipose Tissue
White/metabolism
Animals
Atherosclerosis/prevention & control
Body Weight
Liver/metabolism
Macrophages/physiology
Micronutrients/administration & dosage
Muscle
Skeletal/metabolism
PPAR alpha/physiology
Triglycerides/blood
Micronutrients
chemistry.chemical_classification
0303 health sciences
Fatty liver
Micronutrient
3. Good health
nutrition
Adipose Tissue
Liver
10076 Center for Integrative Human Physiology
10209 Clinic for Cardiology
medicine.symptom
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
Adipose Tissue
White
610 Medicine & health
Biology
2705 Cardiology and Cardiovascular Medicine
lipids
03 medical and health sciences
Physiology (medical)
Internal medicine
medicine
PPAR alpha
PPAR a
Muscle
Skeletal
Triglycerides
030304 developmental biology
atherosclerosis
Macrophages
Original Articles
1314 Physiology
medicine.disease
Metabolic pathway
Endocrinology
chemistry
biology.protein
570 Life sciences
biology
Weight gain
Lipoprotein
Zdroj: Cardiovascular Research
Cardiovascular Research, Oxford University Press (OUP), 2011, 91 (4), pp.732-741. ⟨10.1093/cvr/cvr146⟩
Cardiovascular Research, vol. 91, no. 4, pp. 732-741
Cardiovascular research
Cardiovascular Research 4 (91), 732-741. (2011)
ISSN: 0008-6363
DOI: 10.1093/cvr/cvr146⟩
Popis: International audience; Aims: More than two billion people worldwide are deficient in key micronutrients. Single micronutrients have been used athigh doses to prevent and treat dietary insufficiencies. Yet the impact of combinations of micronutrients in smalldoses aiming to improve lipid disorders and the corresponding metabolic pathways remains incompletely understood.Thus, we investigated whether a combination of micronutrients would reduce fat accumulation and atherosclerosisin mice. Methods and results: Lipoprotein receptor-null mice fed with an original combination of micronutrients incorporated into the daily chowshowed reduced weight gain, body fat, plasma triglycerides, and increased oxygen consumption. These effects wereachieved through enhanced lipid utilization and reduced lipid accumulation in metabolic organs and were mediated, inpart, by the nuclear receptor PPARa. Moreover, the micronutrients partially prevented atherogenesis when administeredearly in life to apolipoprotein E-null mice. When the micronutrient treatment was started before conception,the anti-atherosclerotic effect was stronger in the progeny. This finding correlated with decreased post-prandial triglyceridaemiaand vascular inflammation, two major atherogenic factors. Conclusion: Our data indicate beneficial effects of a combination of micronutritients on body weight gain, hypertriglyceridaemia,liver steatosis, and atherosclerosis in mice, and thus our findings suggest a novel cost-effective combinatorial micronutrient-based strategy worthy of being tested in humans.
Databáze: OpenAIRE
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