Physiologic Effects of Exogenous Dextrose in Murine Klebsiella pneumoniae Sepsis Vary by Route of Provision
| Autor: | Yingze Zhang, Teresa Gallego-Martin, Sagar Rawal, Faraaz Ali Shah, Bryan J. McVerry, Lanping Guo, B. Chuan, Christopher P. O'Donnell, Bryce A. Cooper |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Inflammation lcsh:TX341-641 Systemic inflammation Gastroenterology Enteral administration Sepsis sepsis 03 medical and health sciences Route of administration 0302 clinical medicine Internal medicine medicine pneumonia 030212 general & internal medicine Saline Glycemic Nutrition and Dietetics business.industry 030208 emergency & critical care medicine medicine.disease carbohydrate inflammation Bacteremia hyperglycemia medicine.symptom business lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Nutrients, Vol 12, Iss 2901, p 2901 (2020) Nutrients Volume 12 Issue 10 |
| ISSN: | 2072-6643 |
| Popis: | Sepsis is characterized by a dysregulated immune response to infection. Nutrition is important in the care of septic patients, but the effects of specific nutrients on inflammation in sepsis are not well defined. Our prior work has shown benefits from early enteral dextrose infusion in a preclinical endotoxemia model of sepsis. In the current study, we extend our initial work to examine the effects of dextrose infusions, varying by route of administration, on inflammation and glycemic control in a more clinically relevant and translational model of Klebsiella pneumoniae (KP) bacteremia. Ten-week old C57BL6/J male mice (n = 31) underwent the implantation of indwelling vascular catheters, followed by inoculation with oropharyngeal KP. The mice were randomized 24 h after inoculation to (1) intravenous (IV) dextrose, (2) enteral dextrose, or (3) enteral saline (control) to study the effects on systemic inflammation, hemodynamics, and glycemic control. At 72 h, 77% of the control mice died, whereas IV dextrose induced 100% mortality, associated with increased inflammation, hyperglycemia, and hypotension. Enteral dextrose reduced mortality to 27%, promoted euglycemia, and reduced inflammation compared to IV dextrose. We conclude, in a bacteremic model of sepsis, that enteral (but not IV) dextrose administration is protective, suggesting that the route of nutrient support influences inflammation in sepsis. |
| Databáze: | OpenAIRE |
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