Increased circulating Tfh to Tfr ratio in chronic renal allograft dysfunction: a pilot study

Autor: Xiaojuan Wu, Jiangtao Tang, Yunying Shi, Lanlan Wang, Yi Li, Yamei Li, Xianding Wang, Lin Yan
Rok vydání: 2019
Předmět:
Graft Rejection
Male
0301 basic medicine
Allergy
Cell
Pilot Projects
Kidney Function Tests
Logistic regression
Gastroenterology
0302 clinical medicine
HLA Antigens
T-Lymphocyte Subsets
Transforming Growth Factor beta
Follicular phase
B-Lymphocytes
Graft Survival
T-Lymphocytes
Helper-Inducer
CXCL13
Middle Aged
Allografts
Chronic renal allograft dysfunction
medicine.anatomical_structure
Female
Research Article
lcsh:Immunologic diseases. Allergy
Adult
medicine.medical_specialty
Immunology
cTfh to cTfr ratio
Renal function
Immunophenotyping
Young Adult
03 medical and health sciences
Internal medicine
medicine
Humans
Lymphocyte Count
Risk factor
B cell
business.industry
medicine.disease
Chemokine CXCL13
Kidney Transplantation
030104 developmental biology
T follicular helper cells
T follicular regulatory cells
lcsh:RC581-607
business
Biomarkers
030215 immunology
Zdroj: BMC Immunology
BMC Immunology, Vol 20, Iss 1, Pp 1-11 (2019)
ISSN: 1471-2172
DOI: 10.1186/s12865-019-0308-x
Popis: Background T follicular helper (Tfh) cells play a control role in contribution of B cell differentiation and antibody production. T follicular regulatory (Tfr) cells inhibit Tfh-B cell interaction. Methods To identify whether circulating Tfh (cTfh) and Tfr (cTfr) cells contribute to chronic renal allograft dysfunction (CAD), 67 kidney transplant recipients (34 recipients with CAD, 33 recipients with stable function) were enrolled. The frequency of cTfh and cTfr cells, the level of serum CXCL13 were measured. Results The frequency of cTfr cells in CAD group was significantly lower than that in stable group (0.31% vs 0.68%, P = 0.002). The cTfh to cTfr ratio in CAD group was significantly higher than that in stable group (55.4 vs 25.3, P = 0.013). Serum CXCL13 in CAD group was significantly higher than stable group (30.4 vs 21.9 ng/ml, P = 0.025). After linear regression analysis, the cTfh to cTfr ratio was an independent risk factor for estimated glomerular filtration rate (eGFR) in recipients (standardized coefficient = − 0.420, P = 0.012). After logistic regression analysis, the cTfh to cTfr ratio was an independent risk factor for CAD (OR = 1.043, 95%CI = 1.004–1.085, P = 0.031). Conclusion The imbalance between cTfh and cTfr cells contribute to the development of CAD. Electronic supplementary material The online version of this article (10.1186/s12865-019-0308-x) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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