Maternal and perinatal outcomes in 143 Danish women with gestational diabetes mellitus and 143 controls with a similar risk profile
| Autor: | Henning Beck-Nielsen, Jes G. Westergaard, Dorte Møller Jensen, Bente Sørensen, N Feilberg-Jørgensen |
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| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: |
Adult
Blood Glucose medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Birth weight Denmark Pregnancy High-Risk Gestational Age Medical Records Body Mass Index Fetal Macrosomia Endocrinology Pregnancy Reference Values Risk Factors Diabetes mellitus Internal Medicine medicine Fetal macrosomia Maternal hypertension Birth Weight Humans Caesarean section Labor Induced Retrospective Studies Obstetrics business.industry Cesarean Section Infant Newborn Pregnancy Outcome Gestational age nutritional and metabolic diseases Glucose Tolerance Test medicine.disease Gestational diabetes Diabetes Gestational Parity embryonic structures Apgar Score Female business Infant Premature Maternal Age |
| Zdroj: | Jensen, D M, Sørensen, B, Feilberg-Jørgensen, N, Westergaard, J G & Beck-Nielsen, H 2000, ' Maternal and perinatal outcomes in 143 Danish women with gestational diabetes mellitus and 143 controls with a similar risk profile ', Diabetic Medicine, vol. 17, no. 4, pp. 281-6 . University of Southern Denmark |
| Popis: | Aims To assess maternal and fetal outcomes in pregnancies complicated by gestational diabetes mellitus (GDM) compared to non-diabetic pregnancies with an otherwise similar risk profile and to study the association between different anti-diabetic treatments and fetal outcomes. Methods The records of 143 consecutive GDM pregnancies and 143 non-diabetic controls matched on the basis of age, parity and pre-pregnancy body mass index (BMI) were studied. The GDM patients were treated with diet, tolbutamide and insulin. Data were collected from medical records and birth records. Results Despite treatment, the GDM group had a statistically significant higher frequency of maternal hypertension (20% vs. 11%), induction of labour (61% vs. 24%), Caesarean section (33% vs. 21%), macrosomia (14% vs. 6%), neonatal hypoglycaemia (24% vs. 0) and admission to a neonatal unit (46% vs. 12%). The risk of complications was similar in the different treatment groups. However, in the tolbutamide-treated group, one case of long-standing severe hypoglycaemia in a premature neonate occurred. Conclusions Pregnancies complicated by GDM are associated with a higher frequency of adverse maternal and fetal outcomes. The outcomes seem to be unaffected by treatment modality. However, because of the potential risk of hypoglycaemia in some neonates, tolbutamide treatment cannot be recommended in pregnancy. |
| Databáze: | OpenAIRE |
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