Proton Magnetic Resonance Spectroscopy and MRI Reveal No Evidence for Brain Mitochondrial Dysfunction in Children with Autism Spectrum Disorder
| Autor: | Annette Estes, Neva M. Corrigan, Todd L. Richards, Helen Petropoulos, Seth D. Friedman, Stephen R. Dager, Dennis W. W. Shaw, Alan A. Artru |
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| Rok vydání: | 2011 |
| Předmět: |
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Proton Magnetic Resonance Spectroscopic Imaging Magnetic Resonance Spectroscopy Developmental Disabilities Mitochondrial disease mental disorders Image Processing Computer-Assisted Developmental and Educational Psychology medicine Humans Child medicine.diagnostic_test Brain Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Proton magnetic resonance Mitochondria Child Development Disorders Pervasive Autism spectrum disorder Mitochondrial abnormalities Child Preschool Etiology Autism Female Psychology Neuroscience |
| Zdroj: | Journal of Autism and Developmental Disorders. 42:105-115 |
| ISSN: | 1573-3432 0162-3257 |
| DOI: | 10.1007/s10803-011-1216-y |
| Popis: | Brain mitochondrial dysfunction has been proposed as an etiologic factor in autism spectrum disorder (ASD). Proton magnetic resonance spectroscopic imaging ((1)HMRS) and MRI were used to assess for evidence of brain mitochondrial dysfunction in longitudinal samples of children with ASD or developmental delay (DD), and cross-sectionally in typically developing (TD) children at 3-4, 6-7 and 9-10 years-of-age. A total of 239 studies from 130 unique participants (54ASD, 22DD, 54TD) were acquired. (1)HMRS and MRI revealed no evidence for brain mitochondrial dysfunction in the children with ASD. Findings do not support a substantive role for brain mitochondrial abnormalities in the etiology or symptom expression of ASD, nor the widespread use of hyperbaric oxygen treatment that has been advocated on the basis of this proposed relationship. |
| Databáze: | OpenAIRE |
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