Neutrophil-lymphocyte ratio may be superior to C-reactive protein for predicting the occurrence of postmenopausal osteoporosis
| Autor: | Mukadder Ayse Bilgic, Muzaffer Cakmak, T S Yilmaz, Mehmet Namuslu, A Taskin, Ali Akcay, Nuket Bavbek, Osman Inan, M Uyfun, A Kosar, Hakki Yilmaz |
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| Rok vydání: | 2014 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Bone density Neutrophils Endocrinology Diabetes and Metabolism Osteoporosis Gastroenterology Bone remodeling Endocrinology Bone Density Predictive Value of Tests Risk Factors Internal medicine medicine Humans Lymphocytes Osteoporosis Postmenopausal Aged Femoral neck Bone mineral biology medicine.diagnostic_test business.industry fungi C-reactive protein Complete blood count Middle Aged medicine.disease Bone Diseases Metabolic C-Reactive Protein Cross-Sectional Studies medicine.anatomical_structure Predictive value of tests biology.protein Female business |
| Zdroj: | Endocrine Regulations. 48:25-33 |
| ISSN: | 1336-0329 |
| DOI: | 10.4149/endo_2014_01_25 |
| Popis: | OBJECTIVE Recent studies revealed that inflammation plays a critical role in bone remodeling and the pathogenesis of postmenopausal osteoporosis, a major health concern. Neutrophil-lymphocyte ratio (NLR) is a cost-effective marker of inflammation that has been linked with several diseases. This study aimed to compare NLR and C-reactive protein (CRP) levels in osteopenic, osteoporotic, and control subjects and to assess the correlation between NLR levels, CRP, and bone mineral density (BMD) in postmenopausal women. METHODS In this cross-sectional study, the relationship between NLR, CRP, and BMD in 438 women was investigated using uni- and multivariate analyses. BMD (g/cm²) was measured by dual-energy X-ray absorptiometry (DEXA) at the lumbar spine and femur. Complete blood count (CBC), CRP, glucose/lipid metabolism, and established risk factors were determined. RESULTS In the osteoporotic group, NLR and CRP levels were found to be elevated as compared to the osteopenic and control groups (NLR: 4.68 ± 0.72, 3.17 ± 0.43, 2.01 ± 0.54; CRP: 12.3 ± 4.1, 4.1 ± 2.7, 3.2 ± 2.1, respectively). A negative correlation was present between NLR and the lumbar spine (L2-L4) and femoral neck BMD after adjusting other risk factors. There was no correlation between CRP levels and BMD after adjusting other risk factors. NLR was significantly associated with L2-L4 BMD (s = -0.653, p |
| Databáze: | OpenAIRE |
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