Water-Templated, Polysaccharide-rich Bioartificial 3D Microarchitectures as Extra-Cellular Matrix Bioautomatons
| Autor: | Bayazeed Alam, Mehak Chauhan, Aneesh Chandrasekharan, Souvik Das, Alpana Sharma, Deepa Suhag, Swati Kaushik, Avanish S. Parmar, T.R. Santhoshkumar, Deepa Ghosh, Shaohua Ma, Sonu Gandhi |
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| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Materials science Tissue Engineering Tissue Scaffolds Reproducibility of Results Antineoplastic Agents Hydrogels Polysaccharide Extracellular Matrix Polymerization Extracellular matrix Mannans chemistry Acrylates Biomimetic Materials Cell Line Tumor Spheroids Cellular Biophysics Humans Methacrylates General Materials Science Camptothecin Drug Screening Assays Antitumor Porosity Etoposide |
| Zdroj: | ACS applied materialsinterfaces. 12(18) |
| ISSN: | 1944-8252 |
| Popis: | This is the first report of exploiting the "quasi-spherical" shape of water molecules for recapitulating a true human extracellular matrix (ECM). Herein, water behaved as a quasi-spherical porogen, for engineering polysaccharide-rich and chemically defined 3D-microarchitecture, with semi-interpenetrating networks (S-IPNs). Furthermore, their viscoelastic behavior along with a heterogeneous, fibroporous morphology, facilitated instructive, self-remodeling of the bioartificial scaffolds, thence effectively permitting and promoting the growth of 3D tumor spheroids of divergent origins. The hybrid composites displayed reproducible, uniform tumor spheroids with a |
| Databáze: | OpenAIRE |
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