Moderate Weight Loss Reduces Renin and Aldosterone but does not Influence Basal or Stimulated Pituitary-adrenal Axis Function
| Autor: | Jui T. Ho, P.M. Clifton, Monika Ehrhart-Bornstein, John G. Lewis, Jennifer B Keogh, Stefan R. Bornstein, David J. Torpy |
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| Přispěvatelé: | Ho, J, Keogh, Jennifer Beatrice, Bornstein, S, M, Lewis, J, Clifton, Peter, Torpy, D |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Mean arterial pressure Diet Reducing Hydrocortisone Endocrinology Diabetes and Metabolism Clinical Sciences Clinical Biochemistry Pituitary-Adrenal System Blood Pressure Biochemistry Reducing Female Humans Middle Aged Obesity Renin Renin-Angiotensin System Sodium Chloride chemistry.chemical_compound Endocrinology Weight loss Internal medicine Weight Loss Renin–angiotensin system medicine aldosterone corticotropin cortisone renin transcortin EMTREE medical terms: adult aged body mass conference paper diastolic blood pressure diet restriction female hormone blood level human hypophysis adrenal system major clinical study male obesity priority journal systolic blood pressure urinalysis weight reduction MeSH: Adult Aged Aldosterone Body Weight Caloric Restriction Cosyntropin Cross-Over Studies Diet [EMTREE drug terms] Sodium Chloride Dietary Salt intake Transcortin medicine.diagnostic_test Biochemistry (medical) ACTH stimulation test General Medicine Dietary Blood pressure chemistry medicine.symptom Cortisone medicine.drug |
| Zdroj: | Hormone and Metabolic Research. 39:694-699 |
| ISSN: | 1439-4286 0018-5043 |
| DOI: | 10.1055/s-2007-985354 |
| Popis: | Body fat mass and nutrition influence secretion of the adrenocortical hormones--aldosterone and cortisol--via several mechanisms. However, there are no data on adrenocortical function following widely prescribed mild diet-induced weight loss (10%) in obese subjects. In the present study, 25 healthy obese volunteers (BMI 32.9+/-4.3 kg/m (2)) followed a 30% calorie restricted diet over 12 weeks. Hypothalamic-pituitary-adrenal (HPA) axis function was assessed by 24-hour urine free cortisol/cortisone and a 1 mcg ACTH stimulation test with measurement of total and free cortisol and corticosteroid-binding globulin (CBG). The renin-angiotensin-aldosterone system (RAAS) was assessed by measurement of plasma aldosterone and renin under salt depleted (30 mmol/d) and loading (250 mmol/d) conditions. Volunteers' weight fell by 8.5+/-0.8 kg (8.9+/-0.7%) and seated systolic blood pressure fell by 8.7+/-2.7 mmHg and diastolic blood pressure by 7.0+/-1.4 mmHg (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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