Acquired Pelger-Huët anomaly/abnormal chromatin clumping of granulocytes after allogeneic hematopoietic stem cell transplantation for acute myeloid leukaemia: medication or relapse?
| Autor: | Aline Schmidt, Anna Zharkova, Marc Zandecki, Laurane Cottin, Iris Henriot, Bénédicte Ribourtout, Jean-Maxime Girard, Aurélien Sutra Del Galy, Pierre Daufresne |
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| Rok vydání: | 2016 |
| Předmět: |
Pathology
medicine.medical_specialty Transplantation Conditioning Drug-Related Side Effects and Adverse Reactions medicine.medical_treatment Early Relapse Hematopoietic stem cell transplantation Granulocyte Diagnosis Differential Recurrence Humans Transplantation Homologous Medicine business.industry Hematopoietic Stem Cell Transplantation Myeloid leukemia General Medicine Middle Aged medicine.disease Chromatin Leukemia Myeloid Acute medicine.anatomical_structure Immunology Cyclosporine Pelger–Huet anomaly Female Myeloid leukaemia Stem cell Pelger-Huet Anomaly business Granulocytes |
| Zdroj: | Annales de biologie clinique. 74:110-116 |
| ISSN: | 0003-3898 |
| Popis: | An acute myeloid leukemia was diagnosed in a 53-year-old female patient. She received an allogeneic stem cell transplant. After this transplant, some neutrophils with hyposegmented nucleus and abnormal chromatin clumping appeared in the peripheral blood, and their number gradually increased. The hypothesis of early relapse after transplant was ruled out and drug-related anomaly was suspected. The authors discuss about morphological features of constitutional and acquired Pelger-Huët anomaly. In the patient reported here, ciclosporine seemed to be involved in the phenomenon, as the morphological anomaly of the neutrophils gradually decreased after the drug was discontinued. |
| Databáze: | OpenAIRE |
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