Clinical and biological significance of RAS mutations in multiple myeloma
| Autor: | Patricia T. Greipp, Kim Henderson, Susanna Jacobus, Wee Joo Chng, B Van Ness, R Fonseca, Natalia Gonzalez-Paz, Robert A. Kyle, Tammy Price-Troska, S Van Wier, S V Rajkumar, Martin M. Oken |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Male
Cancer Research Chromosome Chromosomal translocation Locus (genetics) Hematology Biology medicine.disease Article Malignant transformation Cyclin D1 Cell Transformation Neoplastic Genes ras Oncology hemic and lymphatic diseases Immunology medicine Immunoglobulin heavy chain Humans Female Multiple Myeloma Multiple myeloma Monoclonal gammopathy of undetermined significance |
| Popis: | Primary genetic abnormalities in myeloma (MM) such as trisomies of chromosomes 3, 5, 7, 9, 11, 15, 19 and 21 associated with hyperdiploid MM and translocations involving the immunoglobulin heavy chain (IgH) locus on chromosome 14q32 and three main recurrent partners: MMSET/FGFR3, CCND1 and c-MAF are already present in the pre-malignant monoclonal gammopathy of undetermined significance (MGUS) stage.1 Some patients with these genetic abnormalities may remain as MGUS for many years without transforming to MM, suggesting that they are involved in clonal initiation but do not mediate malignant transformation. |
| Databáze: | OpenAIRE |
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