Hypoprolactinemia and ovarian function
| Autor: | M. Reinilä, Antti Kauppila, Lars Rönnberg, Ulla Puistola, Hannu Martikainen |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty endocrine system diseases media_common.quotation_subject Luteal phase Ovarian Follicle Internal medicine Follicular phase medicine Humans Ovarian follicle Bromocriptine Menstrual Cycle reproductive and urinary physiology Menstrual cycle media_common business.industry Ovary Obstetrics and Gynecology medicine.disease Follicular fluid Prolactin Hypoprolactinemia medicine.anatomical_structure Endocrinology Reproductive Medicine Female Luteinizing hormone business Corpus luteum hormones hormone substitutes and hormone antagonists |
| Zdroj: | Fertility and Sterility. 49:437-441 |
| ISSN: | 0015-0282 |
| Popis: | Thirty-two patients with ovarian hyperstimulation were randomized to receive bromocriptine or placebo from cycle day 5 onward. Bromocriptine decreased serum and follicular fluid prolactin (PRL), accelerated ovarian follicle growth, increased serum and follicular fluid estradiol, lowered luteal phase progesterone, and shortened the luteal phase length of the cycle. The maximal luteal phase estradiol and progesterone concentrations correlated with each other in the placebo group, but not in the bromocriptine group. These findings indicate that hypoprolactinemia interferes with ovarian function. The unchanged concentrations of gonadotropic hormones and pattern of luteinizing hormone pulsation during bromocriptine suggest direct ovarian effects of hypoprolactinemia. Because PRL suppression enhanced follicular responses and inhibited corpus luteum formation and function, the follicular and corpus luteum actions of PRL may be different. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|