Risk stratification of coronary plaques using physiologic characteristics by CCTA: Focus on shear stress

Autor: Habib Samady, Anubodh S. Varshney, Ahmet U. Coskun, Bernard De Bruyne, Peter Stone, David Molony
Rok vydání: 2020
Předmět:
medicine.medical_specialty
Computed Tomography Angiography
Plaque growth
Coronary Artery Disease
030204 cardiovascular system & hematology
Mechanotransduction
Cellular
Risk Assessment
Article
030218 nuclear medicine & medical imaging
03 medical and health sciences
Coronary circulation
0302 clinical medicine
Predictive Value of Tests
Risk Factors
Coronary Circulation
Internal medicine
medicine
Shear stress
Animals
Humans
Radiology
Nuclear Medicine and imaging
Computed tomography angiography
Rupture
Spontaneous
medicine.diagnostic_test
business.industry
Hemodynamics
Models
Cardiovascular
Coronary Vessels
Plaque
Atherosclerotic
medicine.anatomical_structure
Risk stratification
Disease Progression
cardiovascular system
Cardiology
Disturbed flow
Stress
Mechanical
Tomography
Tomography
X-Ray Computed
Cardiology and Cardiovascular Medicine
business
Intravascular imaging
circulatory and respiratory physiology
Zdroj: J Cardiovasc Comput Tomogr
ISSN: 1934-5925
Popis: The identification of factors determining whether a lesion progresses, destabilizes or becomes quiescent remains a challenge. Wall or endothelial shear stress (WSS or ESS, respectively), the frictional force acting on the lumen wall, is strongly associated with changes in the natural history of lesions. Several clinical intravascular imaging studies have shown a clear link between disturbed flow, typically characterized by low WSS, and plaque growth. In support of these studies, in-vitro experiments of shear stress have identified several mechanisms promoting atherosclerosis. More recently, the relationship between WSS and major adverse cardiac events has been explored. Improvements in coronary computed tomography angiography (CCTA) image resolution and quality has allowed for the calculation of WSS from CT. In this review, we provide an introduction to WSS, highlight important human and animal intravascular-based WSS studies, and discuss CT-based WSS studies to date. Finally, we discuss future directions of CCTA and WSS computation.
Databáze: OpenAIRE
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