Effects of anti-neoplastic agents on the recovery of bacteria and yeasts in an automated blood culture system
| Autor: | Urpo Kinnunen, Markku Koskela, Pirjo Koistinen, Hannu Syrjälä |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Microbiology (medical)
Gram-Negative Facultatively Anaerobic Rods Gram-negative bacteria medicine.drug_class Gram-positive bacteria Antibiotics Antineoplastic Agents Microbiology Yeasts medicine Humans Blood culture Anti neoplastic Etoposide Bacteriological Techniques General Immunology and Microbiology medicine.diagnostic_test biology Dose-Response Relationship Drug Medical screening General Medicine biology.organism_classification Yeast Culture Media Gram-Positive Cocci Infectious Diseases Doxorubicin human activities Bacteria |
| Zdroj: | Scandinavian journal of infectious diseases. 32(1) |
| ISSN: | 0036-5548 |
| Popis: | The effects of 7 anti-neoplastic agents on the recovery of 5 aerobic gram-positive cocci, gram-negative rods and yeasts were studied in 2 different automated blood culture systems using an experimental model. In the absence of anti-neoplastic agents, the growth of gram-positive cocci was detected significantly earlier in standard than in FAN aerobic bottles. In the presence of 100 microM doxorubicin, however, the growth of gram-positive cocci was totally inhibited in standard culture conditions, while in FAN bottles the agent has no inhibitory effect. Etoposide at a concentration of 100 micromol/l also significantly delayed the growth of cocci in standard conditions. Neither the culture bottles nor the anti-neoplastic agents tested had any effect on the growth of gram-negative rods and yeasts. The results suggest that the anti-neoplastic agents present in blood might disturb the growth of gram-positive cocci in blood culture. This should be considered when validating blood culture systems and evaluating blood cultures of chemotherapy-receiving febrile patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|