Identification of novel small-molecular inhibitors of Staphylococcus aureus sortase A using hybrid virtual screening

Autor:	Galyna P. Volynets, Fabian Barthels, Stefan J. Hammerschmidt, Olena V. Moshynets, Sergiy S. Lukashov, Sergiy A. Starosyla, Hanna V. Vyshniakova, Olga S. Iungin, Volodymyr G. Bdzhola, Andrii O. Prykhod’ko, Anatolii R. Syniugin, Vladislav M. Sapelkin, Sergiy M. Yarmoluk, Tanja Schirmeister
Rok vydání:	2022
Předmět:	Pharmacology Staphylococcus aureus SARS-CoV-2 COVID-19 Microbial Sensitivity Tests Staphylococcal Infections Aminoacyltransferases Anti-Bacterial Agents Cysteine Endopeptidases Bacterial Proteins Biofilms Drug Discovery Humans RNA Viral
Zdroj:	The Journal of Antibiotics. 75:321-332
ISSN:	1881-1469 0021-8820
Popis:	Staphylococcus aureus is one of the most dangerous pathogens commonly associated with high levels of morbidity and mortality. Sortase A is considered as a promising molecular target for the development of antistaphylococcal agents. Using hybrid virtual screening approach and FRET analysis, we have identified five compounds able to decrease the activity of sortase A by more than 50% at the concentration of 200 µM. The most promising compound was 2-(2-amino-3-chloro-benzoylamino)-benzoic acid which was able to inhibit S. aureus sortase A at the IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9070f741f09bac54f92b8fed82646a1 https://doi.org/10.1038/s41429-022-00524-8 Zobrazit plný text záznamu Full text from SpringerLink