Past appendectomy may be related to early cognitive dysfunction in Parkinson's disease
| Autor: | Alexandre Mendes, Alexandra R. Gonçalves, Nuno Vila-Chã, Joana Fernandes, Joana Damásio, Sara Cavaco |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Neurology Parkinson's disease Perseveration Apathy Late onset Dermatology Hospital Anxiety and Depression Scale 03 medical and health sciences 0302 clinical medicine Rating scale Internal medicine medicine Dementia Appendectomy Humans Cognitive Dysfunction 030212 general & internal medicine business.industry Parkinson Disease General Medicine medicine.disease Psychiatry and Mental health England Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 42(1) |
| ISSN: | 1590-3478 |
| Popis: | The vermiform appendix is a potential site of initiation of Parkinson’s disease (PD) pathology. We hypothesized that the appendectomy earlier in life may alter the clinical expression of PD. To explore the effects of appendectomy prior to onset of PD motor symptoms on patients’ symptoms, in particular on cognitive dysfunction. Two hundred and sixty-two consecutive PD patients were asked about past history of appendectomy and underwent an evaluation, which included the Unified Parkinson’s Disease Rating Scale (UPDRS), Hoehn & Yahr scale (H&Y), Schwab & England Independence Scale (S&E), Dementia Rating Scale-2 (DRS-2), Apathy Evaluation Scale, Hospital Anxiety and Depression Scale, and Brief Smell Identification Test. Motor symptoms were evaluated in OFF and ON states. Non-parametric group comparisons and logistic regressions were used for data analyses. Thirty-one patients (11.8%) had history of appendectomy prior to PD onset. These patients had more severe motor symptoms (UPDRS-III and H&Y) and lower functional independence (S&E) in ON and had higher frequency of cognitive dysfunction (DRS-2 Initiation/Perseveration, Conceptualization, and Memory subscales) (p |
| Databáze: | OpenAIRE |
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