Dynamic distribution and dosimetric evaluation of human non-specific immunoglobulin G labelled with 111In or 99Tcm
| Autor: | Roland A. M. J. Claessens, Jeffry A. Siegel, J.W.M. van der Meer, O.C. Boerman, F.H.M. Corstens, W.C.A.M. Buijs, Wim J.G. Oyen, E.T.M. Dams |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Urine Infections Radiation Dosage Effective dose (radiation) Immunoglobulin G Excretion Febris e causa ignota Pharmacokinetics Non specific Humans Dosimetry Tissue Distribution Radiology Nuclear Medicine and imaging Aged Inflammation Fever of unknown origin Detection of inflammatory processes with radiolabeled proteins biology Chemistry business.industry Indium Radioisotopes Organotechnetium Compounds General Medicine Middle Aged Detectie van ontstekingsprocessen met radioactief gelabelde eiwitten Radioimmunodetection biology.protein Female Radiopharmaceuticals Nuclear medicine business Technetium-99m |
| Zdroj: | Europe PubMed Central Nuclear Medicine Communications, 19, pp. 743-751 Nuclear Medicine Communications, 19, 743-751 |
| ISSN: | 0143-3636 |
| DOI: | 10.1097/00006231-199808000-00004 |
| Popis: | This study presents data on the dynamic distribution and dosimetry of 111 In- and 99 Tc m -labelled human non-specific immunoglobulin G (IgG), two recently developed radiopharmaceuticals for the detection of infection and inflammation. Five healthy volunteers were injected with 20-75 MBq 111 In-IgG and seven patients were injected with 740 MBq 99Tcm-hydrazinonicotinamide derivative (HYNIC)-IgG. Blood samples, urine and feces were collected. Whole-body gamma camera imaging studies were performed. The activity in source organs was quantified using the conjugate view counting method and a partial background subtraction technique. Dosimetric calculations were performed using the MIRD technique. For 111 In-IgG, the mean biological half-times in the blood were 0.90 and 46 h for the a- and b-phase, respectively. For 99 Tc m -HYNIC-IgG, these half-times were 0.46 and 45 h. For 111 In-IgG, the mean cumulative urinary excretion in the first 48 h was 18% of the injected dose, while excretion in the feces was less than 2% of the injected dose. For 99 Tc m -HYNIC-IgG, the whole-body retention was always 100% up to 24 h. The mean absorbed doses in the liver, spleen, kidneys, red marrow and testes from 111 In-IgG were 0.8, 0.7, 1.2, 0.3 and 0.4 mGy MBq -1 respectively. The mean absorbed doses for 99 Tc m -HYNIC-IgG to these organs were 16, 24, 15, 10 and 22 μGy MBq -1 respectively. The mean effective dose was 0.25 mSv MBq 1 and 8.4 μSv MBq -1 for 111 In-IgG and 99 Tc m -HYNIC-IgG respectively. In conclusion, the radiation absorbed doses for both 111 In-IgG and 99 Tc m -HYNIC-IgG are low and, therefore, these radiopharmaceuticals can be administered safely from a radiation risk perspective. |
| Databáze: | OpenAIRE |
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