Effects of neurosecretory protein GL on food intake and fat accumulation under different dietary nutrient compositions in rats
| Autor: | Keisuke Fukumura, Kenshiro Shikano, Yuaki Narimatsu, Mana Naito, Megumi Furumitsu, Kazuyoshi Ukena, Eiko Iwakoshi-Ukena |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Food intake Sucrose Period (gene) Nerve Tissue Proteins White adipose tissue Biology Applied Microbiology and Biotechnology Biochemistry Energy homeostasis Analytical Chemistry 03 medical and health sciences chemistry.chemical_compound Eating 0302 clinical medicine Nutrient Fat accumulation Internal medicine medicine Animals Mass gain Molecular Biology Dose-Response Relationship Drug Organic Chemistry General Medicine Nutrients Diet Rats 030104 developmental biology Endocrinology chemistry Adipose Tissue 030217 neurology & neurosurgery Biotechnology |
| Zdroj: | Bioscience, biotechnology, and biochemistry. 85(6) |
| ISSN: | 1347-6947 |
| Popis: | We recently identified a novel hypothalamic small protein, named neurosecretory protein GL (NPGL), which is involved in energy homeostasis in birds and mammals. However, whether the action of NPGL is influenced by nutritional composition remains unknown. Thus, we investigated the effect of chronic intracerebroventricular infusion of NPGL for 13 days on feeding behavior and body mass gain under a normal chow (NC) diet, high-fat diet, high-sucrose diet (HSD), and medium-fat/medium-sucrose diet (MFSD) in rats. NPGL stimulated food intake of NC and MFSD, especially during the light period. By contrast, NPGL decreased body mass gain under NC and increased total white adipose tissue mass in HSD- and MFSD-fed rats. These data suggest that the effects of NPGL on feeding behavior, body mass gain, and fat accumulation depend on nutrient type. Among them, sucrose in diets seems to contribute to fat accumulation elicited by NPGL. |
| Databáze: | OpenAIRE |
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