Optimum duration of prophylactic antibiotics in acute non-perforated appendicitis
| Autor: | Simon Kin Hung Wong, Terence M. K. Fung, Yuk-hoi Lam, Kar-Lung Fok, L.M. Mui, Enders K.W. Ng, Sydney S.C. Chung, Calvin S.H. Ng |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Adolescent medicine.drug_class Premedication Antibiotics Postoperative Complications Anti-Infective Agents Metronidazole medicine Clinical endpoint Appendectomy Humans Surgical Wound Infection Abscess Aged Cefuroxime business.industry General Medicine Perioperative Antibiotic Prophylaxis Length of Stay Middle Aged medicine.disease Appendicitis Surgery Anti-Bacterial Agents Treatment Outcome Anesthesia Female business medicine.drug |
| Zdroj: | ANZ journal of surgery. 75(6) |
| ISSN: | 1445-1433 |
| Popis: | Background: The effect of extended prophylactic antibiotic therapy on postoperative infective complications such as wound infection and intra-abdominal abscess for non-perforated appendicitis is poorly defined. Methods: In a randomized controlled trial of 269 patients aged 15–70 years with non-perforated appendicitis undergoing open appendicectomy; 92 received single dose preoperative (group A), 94 received three-dose (group B) and 83 received 5-day perioperative (group C) regimens of cefuroxime and metronidazole. Postoperative infective complication was the primary endpoint. Secondary outcomes included length of hospital stay and complications related to antibiotic therapy. Results: The rate of postoperative infective complication was not significantly different among the groups (6.5% group A, 6.4% group B, 3.6% group C). The duration of antibiotic therapy had no significant effect on the length of hospital stay. Complications related to antibiotic treatment were significantly more common for 5-day perioperative antibiotic group (C) compared with single dose preoperative antibiotic group (A) (P = 0.048). Conclusion: Single dose of preoperative antibiotics is adequate for prevention of postoperative infective complications in patients with non-perforated appendicitis undergoing open appendicectomy. Prolonging the use of antibiotics can lead to unnecessary antibiotic related complications. |
| Databáze: | OpenAIRE |
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