Autoradiographic evidence of delta-opioid receptor downregulation after prenatal stress in offspring rat brain
| Autor: | Pazos A, Diaz A, Laorden Ml, Milanés Mv, Sanchez |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Offspring Down-Regulation Biology δ-opioid receptor Rats Sprague-Dawley Downregulation and upregulation Pregnancy Stress Physiological Internal medicine Receptors Opioid delta medicine Animals Receptor Pharmacology Brain General Medicine medicine.disease Rat brain Rats Radiography Endocrinology Prenatal stress Prenatal Exposure Delayed Effects Gestation Autoradiography Female |
| Zdroj: | Pharmacology. 60(1) |
| ISSN: | 0031-7012 |
| Popis: | In order to visualize neuroanatomical alterations in specific brain regions, light microscopy autoradiography was carried out on offsprings (postnatal day 10) from female rats stressed in different periods of gestation and controls. Group 1 was subjected to restraint stress from day 2 to 6; group 2, from day 7 to 11; group 3, from day 12 to 16; group 4 from day 2 to 16. Group 2 showed decreases in δ-opioid receptor density in different hypothalamic regions. The decrease in δ-opioid receptor density was less marked in groups 1 and 3 whereas there was no modification in group 4. Present data suggest that the prenatal stress induces a downregulation of δ-receptors in different hypothalamic regions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|