Efficacy of oxycodone/acetaminophen and codeine/acetaminphen vs conventional therapy in ederly women with persistent moderate to severe osteoarthritis pain
| Autor: | Mario Bo, Gianluca Isaia, Marco Astengo, Massimiliano Massaia, Antonia Gatti, Mario Molaschi, Elisa Martinelli, Giuliana Michelis, Alessandro Sona, Mauro Zanocchi, Gianfranco Fonte, Laura Corsinovi |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Aging
Health (social science) Activities of daily living Pain Osteoarthritis Oxycodone/Acetaminophen law.invention Randomized controlled trial law medicine Humans Single-Blind Method Adverse effect Acetaminophen Aged Cyclooxygenase 2 Inhibitors Codeine business.industry Anti-Inflammatory Agents Non-Steroidal Analgesics Non-Narcotic medicine.disease Analgesics Opioid Drug Combinations Anesthesia Female Geriatrics and Gerontology business Gerontology Oxycodone medicine.drug |
| Popis: | We aimed to evaluate the efficacy and safety of oxycodone/acetaminophen (O/A) and codeine/acetaminophen (C/A) vs. conventional therapy (CT) without opioids in older women suffering from osteoarthritis (OA)-related pain, sub-optimally responsive to prior conventional treatments. We performed a 6 week, randomized, single blind, controlled study in three nursing homes. We enrolled 154 women with painful OA. They were assigned to treatment with O/A (n=52) and C/A (n=52) vs. CT (n=50). We evaluated at baseline and at week 6: average pain in the last week (mean pain, MeP), pain at rest (RP), pain in movement (MP) (numeric rating scale, NRS); depressive symptoms (Beck Depression Inventory-II, BDI-II); functional status (activities of daily living, ADL) and cognitive status (mini mental state evaluation, MMSE). We considered the adverse events (AEs) in the study period. At week 6, MeP, RP and MP were significantly reduced in all three groups (p |
| Databáze: | OpenAIRE |
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