Recombinant Strains of Human Parechovirus in Rural Areas in the North of Brazil

Autor: Antonio Charlys da Costa, Márcia Cristina Alves Brito Sayão Lobato, Eric Delwart, Cassia Vitória de Deus Alves Soares, Ester Cerdeira Sabino, Élcio Leal, Adriana Luchs, Flavio Augusto de Pádua Milagres, Steven S. Witkin, Fabiola Villanova, Xutao Deng, Shirley Vasconcelos Komninakis, Maria de Fátima Neves dos Santos Abrão, Danielle Elise Gill, Rogério Togisaki das Chagas, Rafael Brustulin
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Viruses, Vol 11, Iss 6, p 488 (2019)
Viruses
Viruses, vol 11, iss 6
Volume 11
Issue 6
ISSN: 1999-4915
Popis: We characterized the 24 nearly full-length genomes of human parechoviruses (PeV) from children in the north of Brazil. The initial phylogenetic analysis indicated that 17 strains belonged to genotype 1, 5 to genotype 4, and 1 to genotype 17. A more detailed analysis revealed a high frequency of recombinant strains (58%): A total of 14 of our PeV-As were chimeric, with four distinct recombination patterns identified. Five strains were composed of genotypes 1 and 5 (Rec1/5)
five strains shared a complex mosaic pattern formed by genotypes 4, 5, and 17 (Rec4/17/5)
two strains were composed of genotypes 1 and 17 (Rec1/17)
and two strains were composed of genotype 1 and an undetermined strain (Rec1/und). Coalescent analysis based on the Vp1 gene, which is free of recombination, indicated that the recombinant strains most likely arose in this region approximately 30 years ago. They are present in high frequencies and are circulating in different small and isolated cities in the state of Tocantins. Further studies will be needed to establish whether the detected recombinant strains have been replacing parental strains or if they are co-circulating in distinct frequencies in Tocantins.
Databáze: OpenAIRE
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