Recombinant Strains of Human Parechovirus in Rural Areas in the North of Brazil
Autor: | Antonio Charlys da Costa, Márcia Cristina Alves Brito Sayão Lobato, Eric Delwart, Cassia Vitória de Deus Alves Soares, Ester Cerdeira Sabino, Élcio Leal, Adriana Luchs, Flavio Augusto de Pádua Milagres, Steven S. Witkin, Fabiola Villanova, Xutao Deng, Shirley Vasconcelos Komninakis, Maria de Fátima Neves dos Santos Abrão, Danielle Elise Gill, Rogério Togisaki das Chagas, Rafael Brustulin |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Rural Population
0301 basic medicine lcsh:QR1-502 Parechovirus lcsh:Microbiology Coalescent theory law.invention Feces law Genotype Viral Child Phylogeny Recombination Genetic Genetics virome Genome biology Phylogenetic tree Strain (biology) Human parechovirus Middle Aged coalescent Gastroenteritis Infectious Diseases Child Preschool Recombinant DNA RNA Viral Sequence Analysis Reassortant Viruses Brazil Biotechnology 030106 microbiology Genome Viral Microbiology Article Viral Proteins 03 medical and health sciences Genetic Virology Humans Human virome Preschool parechovirus Picornaviridae Infections Genetic Variation Infant DNA Sequence Analysis DNA biology.organism_classification recombination 030104 developmental biology picornavirus RNA |
Zdroj: | Viruses, Vol 11, Iss 6, p 488 (2019) Viruses Viruses, vol 11, iss 6 Volume 11 Issue 6 |
ISSN: | 1999-4915 |
Popis: | We characterized the 24 nearly full-length genomes of human parechoviruses (PeV) from children in the north of Brazil. The initial phylogenetic analysis indicated that 17 strains belonged to genotype 1, 5 to genotype 4, and 1 to genotype 17. A more detailed analysis revealed a high frequency of recombinant strains (58%): A total of 14 of our PeV-As were chimeric, with four distinct recombination patterns identified. Five strains were composed of genotypes 1 and 5 (Rec1/5) five strains shared a complex mosaic pattern formed by genotypes 4, 5, and 17 (Rec4/17/5) two strains were composed of genotypes 1 and 17 (Rec1/17) and two strains were composed of genotype 1 and an undetermined strain (Rec1/und). Coalescent analysis based on the Vp1 gene, which is free of recombination, indicated that the recombinant strains most likely arose in this region approximately 30 years ago. They are present in high frequencies and are circulating in different small and isolated cities in the state of Tocantins. Further studies will be needed to establish whether the detected recombinant strains have been replacing parental strains or if they are co-circulating in distinct frequencies in Tocantins. |
Databáze: | OpenAIRE |
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