Rivaroxaban - an oral, direct Factor Xa inhibitor - has potential for the management of patients with heparin-induced thrombocytopenia
| Autor: | Walter Jeske, Mamdouh Bakhos, Debra Hoppensteadt, Harry L. Messmore, Jeanine M. Walenga, Jyothi Maddineni, Margaret Prechel, Omer Iqbal |
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| Rok vydání: | 2008 |
| Předmět: |
Platelet Aggregation
medicine.drug_mechanism_of_action medicine.drug_class Morpholines Antithrombin III Factor Xa Inhibitor Thiophenes Pharmacology Arginine Platelet Factor 4 Fondaparinux Argatroban Rivaroxaban Polysaccharides Heparin-induced thrombocytopenia medicine Humans Platelet activation Enoxaparin Autoantibodies Analysis of Variance Sulfonamides business.industry Anticoagulant Anticoagulants Hematology Heparin Low-Molecular-Weight Flow Cytometry Platelet Activation medicine.disease Thrombocytopenia Direct thrombin inhibitor Pipecolic Acids Anesthesia business medicine.drug |
| Zdroj: | British Journal of Haematology. 143:92-99 |
| ISSN: | 1365-2141 0007-1048 |
| DOI: | 10.1111/j.1365-2141.2008.07300.x |
| Popis: | Rivaroxaban is an oral, direct activated Factor Xa (FXa) inhibitor in advanced clinical development for the prevention and treatment of thromboembolic disorders. Currently available anticoagulants include unfractionated heparin (UFH) and low molecular weight heparins (LMWHs); however, their use can be restricted by heparin-induced thrombocytopenia (HIT). HIT is usually caused by the production of antibodies to a complex of heparin and platelet factor-4 (PF4). This study was performed to evaluate, in vitro, the potential of rivaroxaban as an anticoagulant for the management of patients with HIT. UFH, the LMWH enoxaparin, fondaparinux and the direct thrombin inhibitor argatroban were tested to enable comparative analyses. Rivaroxaban did not cause platelet activation or aggregation in the presence of HIT antibodies, unlike UFH and enoxaparin, suggesting that rivaroxaban does not cross-react with HIT antibodies. Furthermore, rivaroxaban did not cause the release of PF4 from platelets and did not interact with PF4, unlike UFH and enoxaparin. These findings suggest that rivaroxaban may be a suitable anticoagulant for the management of patients with HIT. |
| Databáze: | OpenAIRE |
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