Ascorbic acid and amino acid values in the aqueous humor of a patient with Lowe's syndrome
| Autor: | Koji Nitta, Shuichi Yamamoto, Shigeyoshi Hiraki, Shuko Yamamoto, Yoshihiro Kaji, Masayuki Matsumoto, Tetsuya Yamada, Kazuya Tachinami, Seiji Hayasaka |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Intraocular pressure Adolescent genetic structures medicine.medical_treatment Glaucoma Vitrectomy Ascorbic Acid Cataract Extraction Aqueous Humor Renal tubular acidosis Cellular and Molecular Neuroscience Internal medicine medicine Humans Amino Acids Child Chromatography High Pressure Liquid Intraocular Pressure chemistry.chemical_classification business.industry Infant medicine.disease Ascorbic acid Trabeculotomy eye diseases Sensory Systems Pedigree Amino acid Ophthalmology Oculocerebrorenal Syndrome Endocrinology chemistry Child Preschool Aminoaciduria Female sense organs business |
| Zdroj: | Graefe's Archive for Clinical and Experimental Ophthalmology. 235:217-221 |
| ISSN: | 1435-702X 0721-832X |
| DOI: | 10.1007/bf00941762 |
| Popis: | • Background: Aminoaciduria is found in Lowe's syndrome. No studies of concentrations of ascorbic acid and amino acids in the aqueous humor of the syndrome have been performed. We examined these concentrations in a patient with Lowe's syndrome. • Methods: Ascorbic acid and amino acid levels in the aqueous humor and plasma of a male infant were measured by means of high-performance liquid chromatography. The patient, who had congenital cataract, miotic pupils, opaque corneas, glaucoma, aminoaciduria, normal levels of ascorbic acid and amino acid in the plasma, and renal tubular acidosis, underwent trabeculotomy, lensectomy, and anterior vitrectomy in both eyes. • Results: Intraocular pressure in both eyes decreased to within the normal range, but both corneas remained opaque. The amino acid levels in the aqueous humor were similar to those in the plasma, but intracameral ascorbic acid levels were decreased. After topical instillation of ascorbic acid, the corneas became transparent. The proband's mother had good visual acuity but paracentral lens opacities in both eyes. His maternal grandmother had scattered cortical opacities in both lenses. • Conclusion: In this infant with Lowe's syndrome, we found intracameral levels of amino acids similar to those in the plasma. Levels of ascorbic acid in the aqueous humor were decreased. |
| Databáze: | OpenAIRE |
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