Structural and biochemical basis of interdependent FANCI-FANCD2 ubiquitination

Autor:	Kimon Lemonidis, Martin L Rennie, Connor Arkinson, Viduth K Chaugule, Mairi Clarke, James Streetley, Helen Walden
Rok vydání:	2022
Předmět:	General Immunology and Microbiology General Neuroscience Molecular Biology General Biochemistry Genetics and Molecular Biology
Zdroj:	The EMBO journalReferences.
ISSN:	1460-2075
Popis:	Di-monoubiquitination of the FANCI-FANCD2 (ID2) complex is a central and crucial step for the repair of DNA interstrand crosslinks via the Fanconi anaemia pathway. While FANCD2 ubiquitination precedes FANCI ubiquitination, FANCD2 is also deubiquitinated at a faster rate than FANCI, which can result in a FANCI-ubiquitinated ID2 complex (I
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8fbe554624ddf4b4284dae74c0deab7 https://pubmed.ncbi.nlm.nih.gov/36385258 Zobrazit plný text záznamu Plný text