Recent Clinical Developments of Nanomediated Drug Delivery Systems of Taxanes for the Treatment of Cancer
| Autor: | Stijn L.W. Koolen, Ron H.J. Mathijssen, Ruben A G van Eerden |
|---|---|
| Přispěvatelé: | Medical Oncology, Pharmacy |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Biophysics Pharmaceutical Science Bioengineering Antineoplastic Agents 02 engineering and technology Review 010402 general chemistry 01 natural sciences taxane Biomaterials drug delivery systems SDG 3 - Good Health and Well-being Neoplasms Drug Discovery medicine Animals Humans cancer Intensive care medicine Adverse effect Drug Carriers Taxane business.industry nanoparticle Organic Chemistry Cancer General Medicine 021001 nanoscience & nanotechnology medicine.disease nanomedicine 0104 chemical sciences Review article Nanostructures Active compound Drug delivery Taxoids 0210 nano-technology business |
| Zdroj: | International Journal of Nanomedicine International Journal of Nanomedicine, 15, 8151-8166. Dove Medical Press Ltd. |
| ISSN: | 1178-2013 1176-9114 |
| Popis: | Conventional taxanes are used as cornerstone of the chemotherapeutical treatment for a variety of malignancies. Nevertheless, a large proportion of patients do not benefit from their treatment while they do suffer from severe adverse events related to the solvent or to the active compound. Cremophor EL and polysorbate 80 free formulations, conjugates, oral formulations and different types of drug delivery systems are some examples of the several attempts to improve the treatment with taxanes. In this review article, we discuss recent clinical developments of nanomediated drug delivery systems of taxanes for the treatment of cancer. Targeting mechanisms of drug delivery systems and characteristics of the most commonly used taxane-containing drug delivery systems in the clinical setting will be discussed in this review. |
| Databáze: | OpenAIRE |
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