Repetitive Transcranial Magnetic Stimulation (rTMS) Improves Facial Affect Recognition in Schizophrenia
| Autor: | Agnes Lowe, Joachim Cordes, Jürgen Brinkmeyer, Wolfgang Wölwer, Mareke Habakuck, Marcus Streit, Wolfgang Gaebel, Arian Mobascher, Marcus W. Agelink |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Biophysics Prefrontal Cortex Stimulation Audiology lcsh:RC321-571 Young Adult Cognition Double-Blind Method Social cognition Repetitive transcranial magnetic stimulation (rTMS) medicine Humans In patient Cognitive skill Psychiatry lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Facial affect General Neuroscience Middle Aged medicine.disease Transcranial Magnetic Stimulation Facial affect recognition Transcranial magnetic stimulation Facial Expression Affect Schizophrenia Chronic schizophrenia Female Schizophrenic Psychology Neurology (clinical) Psychology Cognition Disorders |
| Zdroj: | Brain Stimulation, Vol 7, Iss 4, Pp 559-563 (2014) |
| Popis: | Objective Facial affect recognition, a basic building block of social cognition, is often impaired in schizophrenia. Poor facial affect recognition is closely related to poor functional outcome; however, neither social cognitive impairments nor functional outcome are sufficiently improved by antipsychotic drug treatment alone. Adjunctive repetitive transcranial magnetic stimulation (rTMS) has been shown to enhance cognitive functioning in both healthy individuals and in people with neuropsychiatric disorders and to ameliorate clinical symptoms in psychiatric disorders, but its effects on social cognitive impairments in schizophrenia have not yet been studied. Therefore, we evaluated the effects of sham-controlled rTMS on facial affect recognition in patients with chronic schizophrenia. Method Inpatients (N = 36) on stable antipsychotic treatment were randomly assigned to double-blind high-frequency (10 Hz) rTMS or sham stimulation for a total of ten sessions over two weeks. In the verum group, each session consisted of 10 000 stimuli (20 trains of 5 s) applied over the left dorsolateral prefrontal cortex at 110% of motor threshold. Facial affect recognition was assessed before (T0) and after (T1) the ten sessions. Results Facial affect recognition improved significantly more after rTMS (accuracy change: mean = 8.9%, SD = 6.0%) than after sham stimulation (mean = 1.6%, SD = 3.5; Cohen's d = 1.45). There was no correlation with clinical improvement. Conclusion Our results indicate that prefrontal 10 Hz rTMS stimulation may help to ameliorate impaired facial affect recognition in schizophrenia. |
| Databáze: | OpenAIRE |
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