Role of the crumbs proteins in ciliogenesis, cell migration and actin organization
Autor: | André Le Bivic, Magali Barthélémy-Requin, Dominique Massey-Harroche, V. I. Aksenova, Elsa Bazellières |
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Přispěvatelé: | Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Collège de France (CdF)-Centre National de la Recherche Scientifique (CNRS), Réseau National des Systèmes Complexes (RNSC), Centre National de la Recherche Scientifique (CNRS)-CPU-CGE-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de la Recherche Agronomique (INRA)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CGE-CPU-Centre National de la Recherche Scientifique (CNRS), Institut de Biologie du Développement de Marseille-Luminy (IBDML), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS) |
Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
animal structures Polarity (physics) Nerve Tissue Proteins [SDV.BC]Life Sciences [q-bio]/Cellular Biology Biology Adherens junction 03 medical and health sciences Cell Movement Ciliogenesis Cell polarity Animals Humans Cell migration Cilia Polarity complexes Eye Proteins Cytoskeleton [SDV.BDD]Life Sciences [q-bio]/Development Biology Actin ComputingMilieux_MISCELLANEOUS Membrane Proteins Cortical actin cytoskeleton Epithelial Cells Adherens Junctions Cell Biology Actins Cell biology 030104 developmental biology Developmental Biology |
Zdroj: | Seminars in Cell and Developmental Biology Seminars in Cell and Developmental Biology, Elsevier, 2017, ⟨10.1016/j.semcdb.2017.10.018⟩ Seminars in Cell and Developmental Biology, 2017, ⟨10.1016/j.semcdb.2017.10.018⟩ Seminars in Cell & Developmental Biology Seminars in Cell & Developmental Biology, 2018, 81, pp.13-20. ⟨10.1016/j.semcdb.2017.10.018⟩ |
ISSN: | 1084-9521 1096-3634 |
Popis: | International audience; Epithelial cell organization relies on a set of proteins that interact in an intricate way and which are called polarity complexes. These complexes are involved in the determination of the apico-basal axis and in the positioning and stability of the cell-cell junctions called adherens junctions at the apico-lateral border in invertebrates. Among the polarity complexes, two are present at the apical side of epithelial cells. These are the Par complex including aPKC, PAR3 and PAR6 and the Crumbs complex including, CRUMBS, PALS1 and PATJ/MUPP1. These two complexes interact directly and in addition to their already well described functions, they play a role in other cellular processes such as ciliogenesis and polarized cell migration. In this review, we will focus on these aspects that involve the apical Crumbs polarity complex and its relation with the cortical actin cytoskeleton which might provide a more comprehensive hypothesis to explain the many facets of Crumbs cell and tissue properties. |
Databáze: | OpenAIRE |
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