[Reproductive and developmental toxicity studies of 6-amidino-2-naphthyl 4(-)[(4,5-dihydro-1H-imidazol-2-yl) amino] benzoate dimethanesulfonate (FUT-187). (IV)--Oral administration to New Zealand white rabbits during the period of fetal organogenesis
| Autor: | Keitaro Terazawa, Kazunori Shimamura, Mikio Terabayashi, Shigeru Kuramoto, Akira Maruden, Norio Hasegawa |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Period (gene) Developmental toxicity Administration Oral Organogenesis Biology Toxicology Body weight Eating Embryonic and Fetal Development Oral administration Pregnancy Internal medicine medicine Animals New zealand white Fetal Death Maternal-Fetal Exchange Fetus Reproduction Body Weight Imidazoles Endocrinology Gestation Female Rabbits |
| Zdroj: | The Journal of toxicological sciences. 17 |
| ISSN: | 0388-1350 |
| Popis: | Oral administration of 6-amidino-2-naphthyl 4(-)[(4,5-dihydro-1H-imidazol-2-yl)amino] benzoate dimethanesulfonate (FUT-187) at doses of 10, 30 and 100 mg/kg was given to New Zealand White rabbits on days 6 to 18 of gestation. The following results were obtained. Decreased food consumption and suppression of body weight gain in dams were observed and these changes contributed to the increase in aborted or prematured births and increased fetal mortality at the 100 mg/kg group. There were changes attributable to FUT-187 on external, skeletal and visceral examinations of fetuses. Based on the above, the no-effect dose level in dams and fetuses in the present study is 30 mg/kg/day. |
| Databáze: | OpenAIRE |
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