Recent advances of targeted therapy in relapsed/refractory acute myeloid leukemia
| Autor: | Jiale Ma, Zheng Ge |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty Myeloid medicine.medical_treatment Salvage therapy Review Article Targeted therapy 03 medical and health sciences 0302 clinical medicine Relapsed/refractory acute myeloid leukemia Recurrence Internal medicine hemic and lymphatic diseases medicine Humans Molecular Targeted Therapy Precision Medicine Salvage Therapy Chemotherapy lcsh:R5-920 business.industry Hematopoietic Stem Cell Transplantation Myeloid leukemia General Medicine Immunotherapy medicine.disease targeted therapy Prognosis Leukemia Leukemia Myeloid Acute medicine.anatomical_structure 030220 oncology & carcinogenesis Bone marrow business lcsh:Medicine (General) novel genetic mutations 030215 immunology |
| Zdroj: | Bosnian Journal of Basic Medical Sciences Bosnian Journal of Basic Medical Sciences (2021) |
| ISSN: | 1840-4812 1512-8601 |
| Popis: | Despite advances in the understanding of disease pathobiology, treatment for relapsed or refractory acute myeloid leukemia (R/R AML) remains challenging. The prognosis of R/R AML remains extremely poor despite chemotherapy and bone marrow transplants. Discoveries on recurrent and novel genetic mutations, such as FLT3-ITD and IDH1/IDH2, critical signaling pathways, and unique molecular markers expressed on the surface of leukemic cells have been under investigation for the management of R/R AML. Other than monoclonal antibodies, diabodies and triabodies are new targeted therapies developed in recent years and will be the new direction of immunotherapy. Targeted agents combined intensive regimens can be viable options for salvage therapy and as bridges to allogeneic transplant. Future directions will focus on novel, efficient and targeted combinations, low-toxicity maintenance, and individualized precision strategies. Here, we review the major recent advances of targeted therapies in the treatment of R/R AML. |
| Databáze: | OpenAIRE |
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