Successful Treatment with Adefovir of One Patient Whose Cryoglobulinemic Vasculitis Relapsed under Lamivudine Therapy and Who was Diagnosed to Have HBV Virologic Breakthrough with YMDD Mutations
| Autor: | Ömer Nuri Pamuk, Necati Çakir, Kenan Midilli, Hasan Umit |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Vasculitis
Hepatitis B virus medicine.medical_specialty Amino Acid Motifs Organophosphonates medicine.disease_cause Gastroenterology Methionine Recurrence Internal medicine Internal Medicine medicine Adefovir Humans Cutaneous Vasculitis Cryoglobulinemic vasculitis Hepatitis Aspartic Acid business.industry Adenine virus diseases Lamivudine General Medicine Middle Aged Hepatitis B medicine.disease Virology digestive system diseases Cryoglobulinemia Mutation Ymdd mutation Tyrosine Female business medicine.drug |
| Zdroj: | Internal Medicine. 45:1213-1215 |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.45.1816 |
| Popis: | We report a patient whose cryoglobulinemic vasculitis recurred due to reactivation of lamivudine-resistant HBV. Our patient with hepatitis B-related cryoglobulinemic vasculitis was administered lamivudine. Her vasculitis regressed, ALT normalized, HBV-DNA became negative. Under lamivudine therapy, her cryoglobulinemic cutaneous vasculitis recurred. ALT increased significantly; it was found that tyrosine-methionine-aspartate-aspartate (YMDD) motif in the DNA polymerase gene had been replaced by YIDD. Adefovir was added to lamivudine. During follow-up, her purpura disappeared, ALT normalized, HBV-DNA became negative. Our patient is the first whose cryoglobulinemic vasculitis recurred under lamivudine, who had a HBV virologic breakthrough with YMDD mutation, and was successfully treated with adefovir. |
| Databáze: | OpenAIRE |
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