Contribution of Glucose Tolerance and Gender to Cardiac Adiposity
| Autor: | Marco Bucci, Pirjo Nuutila, Romina Maggio, Juhani Knuuti, Jussi P. Pärkkä, Ronald Borra, Virva Lepomaki, Riitta Parkkola, Hanna-Riikka Lehto, Riikka Lautamäki, Antti Viljanen, Patricia Iozzo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Clinical Biochemistry TYPE-2 DIABETES-MELLITUS Type 2 diabetes Biochemistry Ventricular Function Left Impaired glucose tolerance Ventricular Dysfunction Left Endocrinology Insulin resistance Internal medicine Diabetes mellitus Glucose Intolerance medicine Humans Obesity PERICARDIAL FAT Triglycerides IN-VIVO Macrovascular disease METABOLIC SYNDROME Glucose tolerance test INSULIN-RESISTANCE medicine.diagnostic_test Adiponectin business.industry Myocardium Biochemistry (medical) Heart VISCERAL ABDOMINAL FAT Glucose Tolerance Test medicine.disease Magnetic Resonance Imaging EPICARDIAL FAT THICKNESS Adipose Tissue Diabetes Mellitus Type 2 CORONARY-ARTERY-DISEASE Female RESONANCE SPECTROSCOPY Metabolic syndrome business MYOCARDIAL TRIGLYCERIDE CONTENT |
| Zdroj: | Journal of Clinical Endocrinology & Metabolism, 94(11), 4472-4482. ENDOCRINE SOC |
| ISSN: | 0021-972X |
| DOI: | 10.1210/jc.2009-0436 |
| Popis: | Context and Objective: To examine whether pericardial and myocardial fat depots may contribute to the association between diabetes and cardiovascular risk, including sex-related differences, and the role of adiponectin, we evaluated data in patients with obesity and without diabetes [nondiabetic (ND)] or with impaired glucose tolerance or type 2 diabetes and in lean ND controls.Methods: Magnetic resonance imaging and spectroscopy were used to measure left ventricular (LV) function and abdominal sc and visceral fat areas to estimate respective masses, pericardial fat depots, and myocardial triglyceride content in 53 subjects (10 lean ND, 25 obese ND, six impaired-glucose-tolerance, and 12 type 2 diabetic patients with macrovascular disease); gender effects and adiponectin levels were evaluated in the available subset of subjects.Results: Myocardial and pericardial fat increased progressively across study groups. They were lower in obese women than men(P = 0.002), but cardiac steatosis caught up in hyperglycemic women(+81% vs. ND, P = 0.01). Adiponectin was inversely related with both fat depots (P Conclusions: We conclude that glycemia, gender, adiponectin, and cardiac workload are associated with, and hyperglycemia and male gender are independent positive predictors of, heart adiposity. Once glucose tolerance becomes impaired, the evolution of cardiac steatosis is more pronounced in women. (J Clin Endocrinol Metab 94: 4472-4482, 2009) |
| Databáze: | OpenAIRE |
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