High KIF2A expression predicts unfavorable prognosis in diffuse large B cell lymphoma

Autor: Xuefen You, Hong Liu, Jianfei Huang, Li Yang, Yaping Zhang, Wenyu Shi, Mengqi Xu, Qingxiu Dang
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Kinesins
Pathogenesis
Antibodies
Monoclonal
Murine-Derived
0302 clinical medicine
International Prognostic Index
Prognostic marker
hemic and lymphatic diseases
Antineoplastic Combined Chemotherapy Protocols
Hematology
Tissue microarray
General Medicine
Middle Aged
Neoplasm Proteins
Gene Expression Regulation
Neoplastic
Survival Rate
Vincristine
030220 oncology & carcinogenesis
Immunohistochemistry
Original Article
Female
Lymphoma
Large B-Cell
Diffuse
Rituximab
KIF2A
Adult
medicine.medical_specialty
Adolescent
Cell Survival
Down-Regulation
Diffuse large B cell lymphoma
Biology
Disease-Free Survival
Cell Line
03 medical and health sciences
Downregulation and upregulation
Internal medicine
Cell Line
Tumor
medicine
Humans
Cyclophosphamide
Survival analysis
Aged
medicine.disease
030104 developmental biology
Doxorubicin
Cancer research
Prednisone
Diffuse large B-cell lymphoma
Zdroj: Annals of Hematology
ISSN: 1432-0584
0939-5555
Popis: Kinesin family member 2A (KIF2A), a conserved motor protein, plays a critical role in the pathogenesis and prognosis of several malignant tumors. The aim of the present study was to investigate KIF2A expression in diffuse large B cell lymphoma (DLBCL), evaluate the association between KIF2A expression and the clinical parameters of the disease, and determine its prognostic value. KIF2A expression was evaluated in 134 DLBCL and 57 reactive hyperplasia samples using immunohistochemistry on a tissue microarray. The correlations between KIF2A expression with clinical parameters and prognosis were estimated using univariate and multivariate analyses. The expression of KIF2A was significantly higher in DLBCL tissue samples compared with those from subjects with reactive hyperplasia (P=0.002). Furthermore, increased expression of KIF2A protein in DLBCL was related to Ann Arbor stage (P=0.027) and international prognostic index (IPI) score (P=0.01). The survival analysis showed that KIF2A expression (P=0.016), serum LDH level (P=0.049), and IPI score (P
Databáze: OpenAIRE
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