Maternal obesity is associated with chorioamnionitis and earlier indicated preterm delivery among expectantly managed women with preterm premature rupture of membranes
| Autor: | George R. Saade, Giuseppe Chiossi, Luis D. Pacheco, Mary Munn, Emily E. Hadley, Andrea Discacciati, Maged M. Costantine |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
medicine.medical_specialty Fetal Membranes Premature Rupture Time Factors Offspring Chorioamnionitis Cerebral palsy 03 medical and health sciences Magnesium Sulfate 0302 clinical medicine Pregnancy Medicine Humans 030212 general & internal medicine Obesity Retrospective Studies 030219 obstetrics & reproductive medicine business.industry Obstetrics Cesarean Section Infant Newborn Pregnancy Outcome Obstetrics and Gynecology Gestational age medicine.disease Pregnancy Complications Pediatrics Perinatology and Child Health Gestation Premature Birth Female business Complication Premature rupture of membranes |
| Zdroj: | The journal of maternal-fetalneonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 32(2) |
| ISSN: | 1476-4954 |
| Popis: | To determine the association between maternal obesity and delivery due to chorioamnionitis prior to labor onset, among expectantly managed women with preterm premature rupture of membranes (pPROM).This was a secondary analysis of a multicenter randomized trial of magnesium sulfate versus placebo to prevent cerebral palsy or death among offspring of women with anticipated delivery at 24-31-week gestation. After univariable analysis, Cox proportional hazard evaluated the association between maternal obesity and chorioamnionitis, while Laplace regression investigated how obesity affects the gestational age at delivery of the first 20% of women developing the outcome of interest.A total of 164 of the 1942 women with pPROM developed chorioamnionitis prior to labor onset. Obese women had a 60% increased hazard of developing such complication (adjusted HR 1.6, 95%CI 1.1-2.1, p = .008), prompting delivery 1.5 weeks earlier, as the 20th survival percentile was 27.2-week gestation (95%CI 26-28.6) among obese as opposed to 28.8 weeks (95%CI 27.4-30.1) (p = .002) among nonobese women.Maternal obesity is a risk factor for chorioamnionitis prior to labor onset. Future studies will determine if obesity is important enough to change the management of latency after pPROM according to maternal BMI. |
| Databáze: | OpenAIRE |
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